STF-31 is a selective inhibitor of glucose transporter 1 (GLUT1), with an IC50 of 1μM. STF-31completely suppressed the glucose uptake activity and induced apoptosis in GLUT1 expressing myeloma cells. Moreover, STF-31 synergistically enhanced the cell death induced by melphalan, doxorubicin, and bortezomib[3]. STF-31 (0.01-10 μM; 10 days) is specifically toxic to RCC4 cells, whereas RCC4/VHL cells are relatively unaffected. RCC4/VHL cells treated with STF-31 (5 μM; 10 days) largely recovery, whereas RCC4 cells under the same conditions does not. STF-31 (1.25-5 μM; 3 days) does not induce autophagy, apoptosis, or DNA damage. STF-31 causes a necrotic cell death. Soluble analog of STF-31 (11.6 mg/kg; i.p.) treatment delays tumor growth in mice with VHL-deficient RCC tumor xenografts[4]. STF-31 (10 mg/kg; i.p.; twice daily for 2 days, followed by once daily for another 3 days) does not affect normal mice body weight, behavior, and ERG responses. STF-31 reduces light-induced CX3CR1gfp/+ mice microglial activation and retinal degeneration[5].
STF-31 细胞研究
细胞系
浓度
检测类型
检测时间
活动说明
数据源
A2780 cells
Function assay
48 h
Inhibition of NAMPT in human A2780 cells assessed as reduction in NAD level after 48 hrs by LC-MS/MS analysis, IC50=0.024 μM
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HCT116 cells
Proliferation assay
96 h
Antiproliferative activity against human HCT116 cells after 96 hrs by CyQuant-based assay, IC50=0.271 μM
24433859
HT1080 cells
Proliferation assay
96 h
Antiproliferative activity against human HT1080 cells after 96 hrs by CyQuant-based assay, IC50=0.213 μM
24433859
MIAPaCa2 cells
Proliferation assay
96 h
Antiproliferative activity against human MIAPaCa2 cells after 96 hrs by CyQuant-based assay, IC50=0.855 μM
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