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SB-743921 HCl {[allProObj[0].p_purity_real_show]}

货号:A654863 同义名: SB-743921;SB-743921 (hydrochloride)

SB-743921 is a potent KIF11 inhibitor with Ki value of 0.1 nM.

SB-743921 HCl 化学结构 CAS号:940929-33-9
SB-743921 HCl 化学结构
CAS号:940929-33-9
SB-743921 HCl 3D分子结构
CAS号:940929-33-9
SB-743921 HCl 化学结构 CAS号:940929-33-9
SB-743921 HCl 3D分子结构 CAS号:940929-33-9
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SB-743921 HCl 纯度/质量文件 产品仅供科研

货号:A654863 标准纯度: {[allProObj[0].p_purity_real_show]}
批次查询: 批次纯度:

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产品名称 Kinesin 其他靶点 纯度
SB-743921 HCl ++++

KSP (P388 cells), IC50: 14.4 nM

KSP, Ki: 0.07 nM

99%+
GSK-923295 ++

CENP-E, Ki: 3.2 nM

99%+
Ispinesib +++

KSP (HsEg5), Ki app: 1.7 nM

99%+
AZ3146 +

Mps1, IC50: ~35 nM

98+%
MPI-0479605 ++

Mps1, IC50: 1.8 nM

99%+
BAY1217389 +++

Mps1, IC50: 0.63 nM

98%
ARQ 621 98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

SB-743921 HCl 生物活性

靶点
  • Kinesin

    KSP (P388 cells), IC50:14.4 nM

    KSP, Ki:0.07 nM

描述 SB-743921 is a second generation, highly potent and active KSP inhibitor with Ki of 0.1 nM, showing no affinity to MKLP1, Kin2, Kif1A, Kif15, KHC, Kif4 and CENP-E.

SB-743921 HCl 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00136513 Solid Tumor Cancer Phase 1 Completed - United States, Pennsylvania ... 展开 >> GSK Investigational Site Pittsburgh, Pennsylvania, United States, 15232 United States, Wisconsin GSK Investigational Site Madison, Wisconsin, United States, 53792 收起 <<
NCT00343564 Non-Hodgkin's Lymphoma ... 展开 >> Hodgkin's Disease 收起 << Phase 1 Phase 2 Completed - United States, New Jersey ... 展开 >> Hackensack University Medical Center Hackensack, New Jersey, United States, 07601 United States, New York Cornell University Medical Center New York, New York, United States, 10021 Memorial Sloan-Kettering Caner Center New York, New York, United States, 10021 Herbert Irving Comprehensive Cancer Center New York, New York, United States, 10032 United States, North Carolina University of North Carolina Chapel Hill, North Carolina, United States, 27599 United States, Tennessee Sarah Cannon Cancer Research Institute Nashville, Tennessee, United States, 37203 Russian Federation Russian Medical Academy of Postgraduate Education Moscow, Russian Federation, 115478 St. Petersburg State PAVLOV Medical University Saint Petersburg, Russian Federation, 197002 收起 <<
NCT00343564 - Completed - -

SB-743921 HCl 参考文献

[1]Holen KD, Belani CP, et al. A first in human study of SB-743921, a kinesin spindle protein inhibitor, to determine pharmacokinetics, biologic effects and establish a recommended phase II dose. Cancer Chemother Pharmacol. 2011 Feb;67(2):447-54.

[2]Tomillero A, Moral MA. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2009 Jan-Feb;31(1):47-57.

SB-743921 HCl 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.81mL

0.36mL

0.18mL

9.03mL

1.81mL

0.90mL

18.07mL

3.61mL

1.81mL

SB-743921 HCl 技术信息

CAS号940929-33-9
分子式C31H34Cl2N2O3
分子量 553.519
别名 SB-743921;SB-743921 (hydrochloride);SB-743921 hydrochloride
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Store in freezer, under -20°C

溶解度

DMSO: 105 mg/mL(189.7 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 10 mg/mL(18.07 mM),配合低频超声,并水浴加热至45℃助溶

动物实验配方
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