Administered orally at a dose of 10 mg/kg daily, Riboflavin supports growth in Swiss albino mice^[4].

At a single oral dose ranging from 1 to 600 mg/kg, Riboflavin demonstrates antinociceptive, antihyperalgesic, and anti-inflammatory effects in various rat models, including those induced by formalin, carrageenan for thermal hyperalgesia, and spinal nerve ligation^[5].

Riboflavin, given intraperitoneally at doses between 3 and 100 mg/kg in a single administration, dose-dependently inhibits the nociceptive response in a mouse model of acetic acid-induced constriction^[6].

Additionally, a single intraperitoneal injection of Riboflavin at doses of 6-12 mg/kg reduces the second-phase nociceptive response in a mouse model of formaldehyde-induced pain^[6].

Following UV irradiation, Riboflavin (5-50 µM, 24 h) exhibits a significant cytotoxic effect on HL60 cells through apoptosis^[2].

Riboflavin (0.76-48.76 nM, 96 h) enhances cell viability and glutathione reductase activity while reducing apoptosis in HepG2 cells in a dose-dependent manner^[3].