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Riboflavin

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Chemical Structure| 83-88-5 同义名 : 核黄素 ;Vitamin B2;E101;Lactoflavin.;Riboflavin, Vitamin B2, Vitamin G
CAS号 : 83-88-5
货号 : A454767
分子式 : C17H20N4O6
纯度 : 98%
分子量 : 376.364
MDL号 : MFCD00005022
存储条件：

粉末 Keep in dark place,Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 16 mg/mL(42.51 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 14 mg/mL(37.2 mM)，配合低频超声，并调节pH至8
动物实验配方：
生物活性
描述 Riboflavin is an orally active micronutrient that is efficiently absorbed and serves as a precursor to flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). These coenzymes are essential for many enzymatic reactions, facilitating electron transfer in biological oxidation-reduction reactions[1].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03319082 - Recruiting July 2023 United States, California ... 展开 >> Stanford University School of Medicine Recruiting Palo Alto, California, United States, 94303 Contact: Theresa Enriquez, COT    650-498-4573    Tenriquez@stanfordhealthcare.org    Principal Investigator: Edward Manche, MD          United States, Minnesota Chu Vision Institute, P.A. Recruiting Bloomington, Minnesota, United States, 55420 Contact: Nic Jacobs    952-835-1235 ext 205    nic.jacobs@chuvision.com    Principal Investigator: Ralph Chu, MD          United States, Ohio Comprehensive EyeCare of Central Ohio Recruiting Westerville, Ohio, United States, 43082 Contact: Donna Coury    614-890-5692    dcoury@compeyecare.com    Principal Investigator: Kenneth Beckman, MD          United States, Pennsylvania Vantage Eye Care, LLC Not yet recruiting Bala-Cynwyd, Pennsylvania, United States, 19004 Contact: Cathy Petrocella, COT    484-434-2706    CPetrocella@oppdoctors.com    Principal Investigator: Brandon Ayres, MD          United States, Texas Slade & Baker Vision Recruiting Houston, Texas, United States, 77027 Contact: Chadisty Pauly    713-626-5544    chad@visiontexas.com    Principal Investigator: Stephen Slade, MD          United States, Utah Hoopes Vision Recruiting Draper, Utah, United States, 84020 Contact: Michele Avila, OD    801-568-0200    mavila@hoopesvision.com    Principal Investigator: Majid Moshirfar, MD          United States, Virginia See Clearly Vision Group Recruiting McLean, Virginia, United States, 22102 Contact: Jenny Suy    703-827-4125    jsuy@seeclearly.com    Principal Investigator: Khoa D Hoang, MD 收起 <<
NCT01097447 - Terminated(Terminated to initi... 展开 >>ate FDA IND-cleared study protocol) 收起 << - United States, California ... 展开 >> Clear View Eye & Laser Medical Center San Diego, California, United States, 92121 United States, Colorado Corneal Consultants of Colorado, P.C Littleton, Colorado, United States United States, Illinois Chicago Cornea Consultants, LTD Hoffman Estates, Illinois, United States United States, Minnesota Minnesota Eye Consultants, P.A. Bloomington, Minnesota, United States, 55431 United States, Texas Cornea Associates of Texas Dallas, Texas, United States, 75231 收起 <<
NCT02709850 Hypertriglyceridemia ... 展开 >> Familial Hypercholesterolemia 收起 << Phase 1 Phase 2 Completed - Canada, Ontario ... 展开 >> Clinical Site Toronto, Ontario, Canada, M9L 3A2 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.66mL

0.53mL

0.27mL

13.29mL

2.66mL

1.33mL

26.57mL

5.31mL

2.66mL
参考文献

[1]Thakur K, et al. Riboflavin and health: A review of recent human research. Crit Rev Food Sci Nutr. 2017 Nov 22;57(17):3650-3660.

[2]de Souza AC, et al. A promising action of riboflavin as a mediator of leukaemia cell death. Apoptosis. 2006 Oct;11(10):1761-71.

[3]Xin Z, et al. Riboflavin deficiency induces a significant change in proteomic profiles in HepG2 cells. Sci Rep. 2017 Apr 3;7:45861.

[4]Agte VV, et al. Effect of riboflavin supplementation on zinc and iron absorption and growth performance in mice. Biol Trace Elem Res. 1998 Nov;65(2):109-15.

[5]Granados-Soto V, et al. Riboflavin reduces hyperalgesia and inflammation but not tactile allodynia in the rat. Eur J Pharmacol. 2004 May 10;492(1):35-40.

[6]França DS, et al. B vitamins induce an antinociceptive effect in the acetic acid and formaldehyde models of nociception in mice. Eur J Pharmacol. 2001 Jun 15;421(3):157-64.