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莱苞迪甙A /Rebaudioside A {[allProObj[0].p_purity_real_show]}

货号:A344662 同义名: A甙甜菊糖 / Glycoside A3 (from S. Rebaudiana);Reb A

Rebaudioside A, an α-glucosidase inhibitor with IC50 of 35.01 μg/mL. is a steviol glycoside isolated and purified from the leaves of Stevia rebaudiana Bertoni..

Rebaudioside A 化学结构 CAS号:58543-16-1
Rebaudioside A 化学结构
CAS号:58543-16-1
Rebaudioside A 3D分子结构
CAS号:58543-16-1
Rebaudioside A 化学结构 CAS号:58543-16-1
Rebaudioside A 3D分子结构 CAS号:58543-16-1
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Rebaudioside A 纯度/质量文件 产品仅供科研

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Rebaudioside A 生物活性

描述 Rebaudioside A is a steviol glycoside. As a α - glucosidase inhibitor, IC50[2]. In vivo, Rebaudioside A (10-9 M) reduced the ATP-sensitive potassium channel (K(ATP)) conductance in a glucose-dependent manner. Moreover, rebaudioside A stimulated the insulin secretion from MIN6 cells in a dose- and glucose-dependent manner[3]. In vitro,Reb A was non-genotoxic in a bone marrow micronucleus test in mice at doses up 750 mg/kg bw and in an unscheduled DNA synthesis test in rats at 2000 mg/kg bw[4].

Rebaudioside A 参考文献

[1]Adari BR, Alavala S, et al. Synthesis of rebaudioside-A by enzymatic transglycosylation of stevioside present in the leaves of Stevia rebaudiana Bertoni. Food Chem. 2016 Jun 1;200:154-8.

[2]Adari BR, Alavala S, George SA, Meshram HM, Tiwari AK, Sarma AV. Synthesis of rebaudioside-A by enzymatic transglycosylation of stevioside present in the leaves of Stevia rebaudiana Bertoni. Food Chem. 2016 Jun 1;200:154-8. doi: 10.1016/j.foodchem.2016.01.033. Epub 2016 Jan 9. PMID: 26830573.

[3]Abudula R, Matchkov VV, Jeppesen PB, Nilsson H, Aalkjaer C, Hermansen K. Rebaudioside A directly stimulates insulin secretion from pancreatic beta cells: a glucose-dependent action via inhibition of ATP-sensitive K-channels. Diabetes Obes Metab. 2008 Nov;10(11):1074-85. doi: 10.1111/j.1463-1326.2008.00864.x. Epub 2008 Apr 22. PMID: 18435771.

[4]Williams LD, Burdock GA. Genotoxicity studies on a high-purity rebaudioside A preparation. Food Chem Toxicol. 2009 Aug;47(8):1831-6. doi: 10.1016/j.fct.2009.04.046. Epub 2009 May 8. PMID: 19427890.

Rebaudioside A 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.03mL

0.21mL

0.10mL

5.17mL

1.03mL

0.52mL

10.34mL

2.07mL

1.03mL

Rebaudioside A 技术信息

CAS号58543-16-1
分子式C44H70O23
分子量 967.013
别名 A甙甜菊糖 ;Glycoside A3 (from S. Rebaudiana);Reb A;Truvia;RA 95;Pure Via;Stevioside A3;Glycoside A3
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,2-8°C

溶解度

DMSO: 105 mg/mL(108.58 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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