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Rebaudioside A
Rebaudioside A
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货号：A344662
同义名：
A甙甜菊糖
/ Glycoside A3 (from S. Rebaudiana); Reb A
Rebaudioside A 是一种α-葡萄糖苷酶抑制剂，IC50值为35.01 μg/mL，是从Stevia rebaudiana Bertoni的叶中提取的甜叶菊苷。
Rebaudioside A 化学结构
Rebaudioside A 3D分子结构
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Rebaudioside A 纯度/质量文件 产品仅供科研
货号：A344662
标准纯度：
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产品说明书
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Rebaudioside A 质控信息
Rebaudioside A 生物活性
描述
Rebaudioside A is a steviol glycoside. As a α - glucosidase inhibitor, IC50 [2] . In vivo , Rebaudioside A (10-9 M) reduced the ATP-sensitive potassium channel (K(ATP)) conductance in a glucose-dependent manner. Moreover, rebaudioside A stimulated the insulin secretion from MIN6 cells in a dose- and glucose-dependent manner[3] In vitro ，Reb A was non-genotoxic in a bone marrow micronucleus test in mice at doses up 750 mg/kg bw and in an unscheduled DNA synthesis test in rats at 2000 mg/kg bw[4]
Rebaudioside A 参考文献
[1] Adari BR, Alavala S, et al. Synthesis of rebaudioside-A by enzymatic transglycosylation of stevioside present in the leaves of Stevia rebaudiana Bertoni. Food Chem. 2016 Jun 1;200:154-8.
[2] Adari BR, Alavala S, George SA, Meshram HM, Tiwari AK, Sarma AV. Synthesis of rebaudioside-A by enzymatic transglycosylation of stevioside present in the leaves of Stevia rebaudiana Bertoni. Food Chem. 2016 Jun 1;200:154-8. doi: 10.1016/j.foodchem.2016.01.033. Epub 2016 Jan 9. PMID: 26830573.
[3] Abudula R, Matchkov VV, Jeppesen PB, Nilsson H, Aalkjaer C, Hermansen K. Rebaudioside A directly stimulates insulin secretion from pancreatic beta cells: a glucose-dependent action via inhibition of ATP-sensitive K-channels. Diabetes Obes Metab. 2008 Nov;10(11):1074-85. doi: 10.1111/j.1463-1326.2008.00864.x. Epub 2008 Apr 22. PMID: 18435771.
[4] Williams LD, Burdock GA. Genotoxicity studies on a high-purity rebaudioside A preparation. Food Chem Toxicol. 2009 Aug;47(8):1831-6. doi: 10.1016/j.fct.2009.04.046. Epub 2009 May 8. PMID: 19427890.
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Rebaudioside A 实验方案
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摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
1.03mL
0.21mL
0.10mL
5.17mL
1.03mL
0.52mL
10.34mL
2.07mL
1.03mL
Rebaudioside A 技术信息
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