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瑞巴派特 /Rebamipide {[allProObj[0].p_purity_real_show]}

货号:A141959 同义名: OPC12759;Proamipide

Rebamipide is an inducer of endogenous prostaglandin, an oxygen-derived free radical scavenger, and a cholecystokinin type 1 (CCK1) receptor inhibitor for inhibiting [125I]BH-CCK-8S with IC50 of 37.7 μM.

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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Rebamipide 化学结构 CAS号:90098-04-7
Rebamipide 化学结构
CAS号:90098-04-7
Rebamipide 3D分子结构
CAS号:90098-04-7
Rebamipide 化学结构 CAS号:90098-04-7
Rebamipide 3D分子结构 CAS号:90098-04-7
规格 价格 会员价 库存 数量
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Rebamipide 纯度/质量文件 产品仅供科研

货号:A141959 标准纯度: {[allProObj[0].p_purity_real_show]}
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Rebamipide 生物活性

描述 Rebamipide, an antiulcer agent, prevents vaious acute experimental gastric mucosal lesions and accelerates the healing of chronic ulcers. Rebamipide has cytoprotective actions in human and animals. It increases PG levels in gastric tissue and protects gastric mucosa from various insults[3]. Rebamipide (10-100 mg/kg i.p.) inhibited dose dependently the formation of gastric lesions induced by necrotizing agent and caused no injury and increased PAS-positive materials in the gastric epithrlial[4]. Treatment of gastric cancer cells with varying doses of rebamipide (0.5-2.0 mg/mL) caused a significant decrease in cell proliferation in a concentration-dependent manner and rebamipide significantly suppressed gastric cancer cell proliferation up to 71% at 24hr[5].

Rebamipide 参考文献

[1]Kato K, Takashima Y, et al. Effect of topical rebamipide on conjunctival goblet cell recovery after vitrectomy. Sci Rep. 2016 Jan 14;6:19516.

[2]Iinuma S, Naito Y, et al. In vitro studies indicating antioxidative properties of rebamipide. Dig Dis Sci. 1998 Sep;43(9 Suppl):35S-39S.

[3] Sun WH, Tsuji S, Tsujii M, et al. Induction of cyclooxygenase-2 in rat gastric mucosa by rebamipide, a mucoprotective agent. J Pharmacol Exp Ther. 2000;295(2):447-452.

[4]Yamasaki K, Kanbe T, Chijiwa T, Ishiyama H, Morita S. Gastric mucosal protection by OPC-12759, a novel antiulcer compound, in the rat. Eur J Pharmacol. 1987;142(1):23-29.

[5]Tanigawa T, Pai R, Arakawa T, Tarnawski AS. Rebamipide inhibits gastric cancer cell growth. Dig Dis Sci. 2007;52(1):240-247.

Rebamipide 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.70mL

0.54mL

0.27mL

13.48mL

2.70mL

1.35mL

26.97mL

5.39mL

2.70mL

Rebamipide 技术信息

CAS号90098-04-7
分子式C19H15ClN2O4
分子量 370.786
别名 OPC12759;Proamipide;Mucosta
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Room Temperature

溶解度

DMSO: 25 mg/mL(67.42 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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