羟丙茶碱 /Proxyphylline
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货号：A325694
同义名：
7-(2-羟丙基)茶碱
/ NSC 163343;Monophylline
Proxyphylline is a xanthine-derivatived antagonists of A1 and A2 adenosine receptors, which relaxe smooth muscles, particularly bronchial muscles.
Proxyphylline 化学结构
Proxyphylline 3D分子结构
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Proxyphylline 纯度/质量文件 产品仅供科研
货号：A325694
标准纯度：
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Proxyphylline 质控信息
ZM241385
✔
99%+
Istradefylline
+++
Adenosine A2A receptor, Ki: 2.2 nM
98%
Reversine
+
human A3 adenosine receptor, Ki: 0.66 μM
98%
SCH58261
++++
bovine A2a, Ki: 2.0 nM
rat A2a, Ki: 2.3 nM
99%+
A2A receptor antagonist 1
++
A2AR, Ki: 4 nM
A1R, Ki: 264 nM
99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
Proxyphylline 生物活性
描述
Proxyphylline is a methylxanthine derivative used as a cardiac stimulant, vasodilator and bronchodilator[1] [2] [3] [4] [5]
Proxyphylline 参考文献
[1] Takeda K, Katano Y, Nakagawa Y, Tsukada T, Nakazawa M. Effects of aminophylline, proxyphylline and a proxyphylline-Melilotus extract-rutin mixture (theoesberiven) on the heart and the coronary circulation. Jpn J Pharmacol. 1977 Oct;27(5):709-20
[2] Kukovetz WR, Pöch G, Holzmann S. Overadditive synergism between theophylline, diprophylline and proxyphylline in tracheal smooth muscle relaxation. Arzneimittelforschung. 1983;33(10):1450-4
[3] Rasmussen FV, Waldorff S, Madsen L. Pharmacokinetics and bronchodilatory effect of proxyphylline and theophylline. Eur J Respir Dis. 1984 Jan;65(1):20-7
[4] Selvig K, Bjerve KS. Inhibition of human lung cyclic nucleotide phosphodiesterases by proxyphylline, theophylline and their metabolites. Acta Pharmacol Toxicol (Copenh). 1982 Sep;51(3):250-2
[5] Kanto J, Allonen H, Kulmala T, Mäntylä R, Tala E. Interaction between proxyphylline and salbutamol. Int J Clin Pharmacol Ther Toxicol. 1981 Aug;19(8):346-9
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Proxyphylline 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
4.20mL
0.84mL
0.42mL
20.99mL
4.20mL
2.10mL
41.97mL
8.39mL
4.20mL
Proxyphylline 技术信息
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