产品说明书
Proxyphylline
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同义名 : | 7-(2-羟丙基)茶碱 ;NSC 163343;Monophylline;Spasmolysin |
| CAS号 : | 603-00-9 | |
| 货号 : | A325694 | |
| 分子式 : | C10H14N4O3 | |
| 纯度 : | 99% | |
| 分子量 : | 238.243 | |
| MDL号 : | MFCD00022833 | |
| 存储条件： |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(440.73 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Proxyphylline is a methylxanthine derivative used as a cardiac stimulant, vasodilator and bronchodilator[1]. Proxyphylline inhibits tracheal PDE-activity and half-maximum relaxation of tracheal smooth muscle is obtained with 100 μg/mL proxyphylline[2]. Proxyphylline exhibits bronchodilatory effect[3]. Proxyphylline inhibits cAMP and cGMP hydrolysis in human lung tissue. The apparent inhibition constant of proxyphylline is 0.06-0.7 mM at low cAMP concentrations and it is 1.0 mM at high cAMP concentrations [4]. In guinea pigs (modified Konzett-Rössler method) the reduction in response to metacholine caused by increasing doses of proxyphylline and salbutamol significantly exceeded that of either drug alone. The combination of oral proxyphylline and salbutamol is clinically useful in increasing drug response without increased adverse effects[5]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
4.20mL 0.84mL 0.42mL |
20.99mL 4.20mL 2.10mL |
41.97mL 8.39mL 4.20mL |
| 参考文献 |
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