There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Prostaglandin E1 (Alprostadil) is a ligand for prostanoid receptors, exhibiting Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM, and 36 nM for mouse EP3, EP4, EP2, IP, and EP1 receptors respectively. It induces vasodilation and inhibits platelet aggregation, being researched as a vasodilator for peripheral vascular diseases[1].[2].[3].
体内研究
Subcutaneously administered at 20 ng/animal/day for four days, it significantly inhibits FGF-induced angiogenesis in mice[2].
体外研究
In experiments, Prostaglandin E1 at concentrations ranging from 1 nM to 10 μM over 48 hours, reduces proliferation of HUVECs (up to 100% inhibition) in the presence of VEGF (20 ng/mL) with an IC50 of 400 nM[2].
Prostaglandin E1 also inhibits VEGF-induced HUVECs migration at doses from 0.01 μM to 10 μM over 6 hours, with an IC50 of 500 nM[2], and restricts in vitro angiogenesis at 1-5 μM over 12-18 hours[2].
Additionally, Prostaglandin E1 increases intracellular cAMP levels in HUVECs within 20 minutes when administered at concentrations from 0.01 μM to 10 μM[2].
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