Ambeed 大中华区 CN | ZH

中文 - ZH English - EN

Ambeed.cn

搜索

关键字搜索批量搜索

首页 收藏 购物车0
首页 /
抑制剂/激动剂
药物研究 酶学
/
小分子阳性药
酶抑制剂 其他抑制剂/激动剂 代谢酶
/
HMGCR
抗炎 单磷酸肌苷脱氢酶抑制剂
/ Pravastatin Sodium

普伐他汀钠 /Pravastatin Sodium {[allProObj[0].p_purity_real_show]}

货号：A128695 同义名： CS-514 sodium;Pravastatin (sodium salt)

Pravastatin Sodium is a competitive HMG-CoA reductase inhibitor with IC50 value of 5.6 μM.

Pravastatin Sodium 化学结构 CAS号：81131-70-6
Pravastatin Sodium 化学结构
CAS号：81131-70-6
Pravastatin Sodium 3D分子结构
CAS号：81131-70-6
Pravastatin Sodium 化学结构 CAS号：81131-70-6
Pravastatin Sodium 3D分子结构 CAS号：81131-70-6
规格 价格 会员价 库存 数量
{[ item.pr_size ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]} 		{[ getRatePrice(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_am, item.pr_size) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} 现货 咨询 - +
购物车0 收藏 询单

Pravastatin Sodium 纯度/质量文件 产品仅供科研

货号：A128695 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Nat. Biomed. Eng., 2024, 8, 1412-1424. Ambeed. [ A538667 , A631746 ]
• JMC, 2024. Ambeed. [ A833302 , A475501 , A341986 , A356070 ]
• BMC Cancer, 2024, 24(1): 1415. Ambeed. [ A809692 , A209020 ]
• J. Am. Soc. Mass Spectrom., 2024, 35(12): 3192-3202. Ambeed. [ A166127 , A902473 , A753371 , A961334 , A292945 , A230770 , A300620 , A1114580 , A1159765 , A206238 ]
• PloS One, 2024, 19(11): e0308060. Ambeed. [ A302917 ]
更多 >

Pravastatin Sodium 生物活性

描述 HMG-CoA reductase, the rate-limiting enzyme in the process of cholesterol synthesis in liver cells, catalyzes the production of mevalonate. Inhibiting HMG-CoA reductase inhibits cholesterol synthesis [3].Pravastatin sodium is an HMG-CoA reductase inhibitor that inhibits sterol synthesis with IC50 value of 5.6 μM[2]. In vitro, in animals and humans , it reduces plasma levels of LDL by inhibiting the synthesis of intracellular cholesterol. Among the three types of macrophages, including J-774 A.1 macrophage-like cells, human monocyte derived macrophages (HMDM) and mouse peritoneal macrophages (MPM), pravastatin sodium reduced intracellular cholesterol synthesis with IC50 of 0.08, 6.3 and 7.8 μg/ml, respectively[4]. Pravastatin sodium also moderates the individual aortic ring, with a maximum blood vessel dilation of 62.8% at 10 μM for 8 minutes. In cultured bovine arterial endothelial cells, Pravastatin sodium (< 10 μM) stimulates NOS activity and releases NO within 10 min, while L-arginine responds to pravastatin sodium (< 10 μM) by enhancing NO production[1]. In vivo, pravastatin (30 mg/kg/day) reduced malnutrition by 34%. In irradiated female wistar rats, CCN2 levels were reduced and Pravastatin (30 mg/kg/day) restored muscle structure[5]. In addition, Pravastatin (40 mg, single dose) reduced cholesterol synthesis rate by 62% in human monocyte derived macrophages and by 47% in patients with high cholesterol. Treatment of patients with elevated serum cholesterol with pravastatin at 40 mg per day for 8 weeks inhibited cholesterol synthesis by 55% and increased LDL degradation by 57%[4].

Pravastatin Sodium 动物研究

Dose Marmosets: 0.03 mg/kg - 30 mg/kg[3] (p.o.) Rat: 10 mg/kg - 100 mg/kg[4] (p.o.) Mice: 200 mg/kg, 250 mg/kg[4] (p.o.)
Administration p.o.

Pravastatin Sodium 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00982189 HIV Infection ... 展开 >> Cardiovascular Disease Risk 收起 << Not Applicable Completed - United States, Minnesota ... 展开 >> Hennepin County Medical Center Minneapolis, Minnesota, United States, 55415 收起 <<
NCT01857921 Coronary Artery Not Applicable Unknown October 2016 Korea, Republic of ... 展开 >> Severance Hospital Recruiting Seoul, Korea, Republic of, 120-752 Contact: Myeong Ki Hong, MD, PhD    82-2-2228-8460    mkhong61@yuhs.ac 收起 <<
NCT00697203 Dyslipidemia Phase 2 Completed - -

Pravastatin Sodium 参考文献

[3]The discovery and development of HMG-CoA reductase inhibitors

Pravastatin Sodium 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.24mL

0.45mL

0.22mL

11.20mL

2.24mL

1.12mL

22.40mL

4.48mL

2.24mL

Pravastatin Sodium 技术信息

CAS号81131-70-6
分子式C23H35NaO7
分子量 446.51
别名 CS-514 sodium;Pravastatin (sodium salt)
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,2-8°C
溶解度

DMSO: 105 mg/mL(235.16 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 50 mg/mL(111.98 mM)
动物实验配方

Tags: Pravastatin | 81131-70-6 | CS-514 | CS514 | CS 514 | HMG-CoA Reductase (HMGCR) Inhibitor | Metabolic Enzyme/Protease | Autophagy | Apoptosis | HMG-CoA Reductase (HMGCR) | Autophagy | Ferroptosis | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Pravastatin Sodium 纯度/质量文件 | Pravastatin Sodium 生物活性 | Pravastatin Sodium 动物研究 | Pravastatin Sodium 临床数据 | Pravastatin Sodium 参考文献 | Pravastatin Sodium 实验方案 | Pravastatin Sodium 技术信息

Ambeed 相关网站 Ambeed.cn Ambeed.com
Ambeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
    • 客户支持
    技术支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    积分商城
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    Ambeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质用途提供服务。

    尊敬的 Ambeed 客户您好，
    请您选择所在区域，我们将转接对应客服为您服务！

    热门区域

    A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z