Pinoresinol diglucoside is one of the major lignans with various pharmacological activities which could be isolated from Duzhong and other plant species.
Pinoresinol diglucoside (PDG) is one of the major lignans with various pharmacological activities which could be isolated from Duzhong and other plant species. PDG (5 mg/kg and 10 mg/kg) exerts anti-inflammatory and antioxidation effects via regulating the NF-κB pathway and Nrf2/HO-1 pathway, thereby reducing the I/R(ischemia/reperfusion)-induced brain injury of mice[3]. PDG (5 and 10 mg/kg, i.g.) can attenuate neuroinflammation, neuronal apoptosis and oxidative stress through the TLR4/NF-κB and Nrf2/HO-1 pathways, and ameliorate memory dysfunction induced by Aβ1-42 in mice[4]. PDG (2.5 mg/kg, 5 mg/kg, 7.5 mg/kg per day) treatment prevented cardiac histomorphology damages, decreased upregulations of hypertrophic biomarkers, and prevented fibrosis and inflammation after pressure overload resulting from AAC(abdominal aortic constriction)-surgery. Consistently, PDG remarkably inhibited the changes of cardiomyocyte hypertrophic biomarkers and inflammatory responses in cellular models of CM. PDG administration inhibited the activation of AKT/mTOR/NF-kB signaling pathway both in vivo and in vitro[5].
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