产品说明书
Pinoresinol Diglucoside
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同义名 : | 松酯醇二葡萄糖苷 ;(+)-Pinoresinol di-O-β-D-glucopyranoside |
| CAS号 : | 63902-38-5 | |
| 货号 : | A468639 | |
| 分子式 : | C32H42O16 | |
| 纯度 : | 98%+ | |
| 分子量 : | 682.666 | |
| MDL号 : | MFCD06656077 | |
| 存储条件： |
粉末 Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(153.81 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Pinoresinol diglucoside (PDG) is one of the major lignans with various pharmacological activities which could be isolated from Duzhong and other plant species. PDG (5 mg/kg and 10 mg/kg) exerts anti-inflammatory and antioxidation effects via regulating the NF-κB pathway and Nrf2/HO-1 pathway, thereby reducing the I/R(ischemia/reperfusion)-induced brain injury of mice[3]. PDG (5 and 10 mg/kg, i.g.) can attenuate neuroinflammation, neuronal apoptosis and oxidative stress through the TLR4/NF-κB and Nrf2/HO-1 pathways, and ameliorate memory dysfunction induced by Aβ1-42 in mice[4]. PDG (2.5 mg/kg, 5 mg/kg, 7.5 mg/kg per day) treatment prevented cardiac histomorphology damages, decreased upregulations of hypertrophic biomarkers, and prevented fibrosis and inflammation after pressure overload resulting from AAC(abdominal aortic constriction)-surgery. Consistently, PDG remarkably inhibited the changes of cardiomyocyte hypertrophic biomarkers and inflammatory responses in cellular models of CM. PDG administration inhibited the activation of AKT/mTOR/NF-kB signaling pathway both in vivo and in vitro[5]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.46mL 0.29mL 0.15mL |
7.32mL 1.46mL 0.73mL |
14.65mL 2.93mL 1.46mL |
| 参考文献 |
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