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Piclidenoson {[allProObj[0].p_purity_real_show]}

货号:A238381 同义名: IB-MECA;CF-101

IB-MECA is an agonist of the adenosine A3 receptor with EC50 values of 0.11 μM. IB-MECA is a potent and selective A3 adenosine receptor agonist with Ki value of 1.1, 54 and 56 nM for A3, A1 and A2A receptors, respectively, which possessing cardioprotective effect and reduces infarct size upon reperfusion in rats.

Piclidenoson 化学结构 CAS号:152918-18-8
Piclidenoson 化学结构
CAS号:152918-18-8
Piclidenoson 3D分子结构
CAS号:152918-18-8
Piclidenoson 化学结构 CAS号:152918-18-8
Piclidenoson 3D分子结构 CAS号:152918-18-8
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Piclidenoson 纯度/质量文件 产品仅供科研

货号:A238381 标准纯度: {[allProObj[0].p_purity_real_show]}
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产品名称 Adenosine Receptor 其他靶点 纯度
ZM241385 99%+
Istradefylline +++

Adenosine A2A receptor, Ki: 2.2 nM

98%
Reversine +

human A3 adenosine receptor, Ki: 0.66 μM

98%
SCH58261 ++++

bovine A2a, Ki: 2.0 nM

rat A2a, Ki: 2.3 nM

99%+
A2A receptor antagonist 1 ++

A1R, Ki: 264 nM

A2AR, Ki: 4 nM

99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Piclidenoson 生物活性

描述 Adenosine receptors play an important role in cell growth and proliferation in different cell lines. The A3 adenosine receptor (A3AR) expression level in normal cells is low, while it is more highly expressed in various tumor cells. IB-MECA is a reversable A3AR agonist, inhibiting the growth of different cancer cell types like melanoma, colon, breast, leukemia, and prostate. IB-MECA was able to inhibit forskolin-stimulated cyclic adenosine monophosphate (cAMP) levels with EC50s of 0.82 μM and 1.2 μM in OVCAR-3 and Caov-4 ovarian cancer cells. Further, IB-MECA exhibited antiproliferative effect with IC50s of 32.14 μM and 45.37 μM for OVCAR-3 and Caov-4 ovarian cancer cells, respectively. 48 h treatment with IB-MECA induced apoptosis in those cell lines with dosage range 0.1-100 μM and significantly reduced cell viability in a dose-dependent manner with dosage range 0.0001-100 μM[3]. In B10CBAF1 male mice aged 3 months, IB-MECA (105 μg/kg) resulted in statistically significant increases of the mean survival time in comparison with the control irradiated mice[4].

Piclidenoson 参考文献

[1]Abedi H, Aghaei M, et al. Mitochondrial and caspase pathways are involved in the induction of apoptosis by IB-MECA in ovarian cancer cell lines. Tumour Biol. 2014 Nov;35(11):11027-39.

[2]Hofer M, Pospisil M, et al. Agonist of the adenosine A3 receptor, IB-MECA, and inhibitor of cyclooxygenase-2, meloxicam, given alone or in a combination early after total body irradiation enhance survival of γ-irradiated mice. Radiat Environ Biophys. 2014 Mar;53(1):211-215.

[3]Abedi H, et al. Mitochondrial and caspase pathways are involved in the induction of apoptosis by IB-MECA in ovarian cancer cell lines. Tumour Biol. 2014 Nov;35(11):11027-39

[4]Shin Y, et al. Activation of Phosphoinositide Breakdown and Elevation of Intracellular Calcium in a Rat RBL-2H3 Mast Cell Line by Adenosine Analogs: Involvement of A(3)-Adenosine Receptors? Drug Dev Res. 1996 Sep 1;39(1):36-46

Piclidenoson 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.96mL

0.39mL

0.20mL

9.80mL

1.96mL

0.98mL

19.60mL

3.92mL

1.96mL

Piclidenoson 技术信息

CAS号152918-18-8
分子式C18H19IN6O4
分子量 510.286
别名 IB-MECA;CF-101;ALB-7208
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Sealed in dry,2-8°C

溶解度

DMSO: 45 mg/mL(88.19 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

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