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/ Pentamidine isethionate

喷他脒羟乙基磺酸盐 /Pentamidine isethionate {[allProObj[0].p_purity_real_show]}

货号：A668797 同义名： 喷他脒羟乙磺酸盐 / MP-601205 isethionate

Pentamidine isethionate (MP-601205 isethionate)是一种干扰 DNA 生物合成的抗微生物剂，以 2.5 μM 的 IC50 抑制利什曼原虫。

Pentamidine isethionate 化学结构 CAS号：140-64-7
Pentamidine isethionate 化学结构
CAS号：140-64-7
Pentamidine isethionate 3D分子结构
CAS号：140-64-7
Pentamidine isethionate 化学结构 CAS号：140-64-7
Pentamidine isethionate 3D分子结构 CAS号：140-64-7
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Pentamidine isethionate 纯度/质量文件 产品仅供科研

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Pentamidine isethionate 生物活性

描述 Pentamidine isethionate, an aromatic diamidine, is an antiprotozoal agent proven to decrease mortality from Pneumocystis carinii pneumonia in debilitated infants and immunodeficient adults and children[3]. The use of intramuscular pentamidine isethionate in the treatment of Leishmania guyanensis cutaneous leishmaniasis is associated with more treatment failures than intravenous pentamidine isethionate[4]. PI (Pentamidine Isethionate) is a safe drug and its efficacy varied with the number of doses. The administration of PI in patients with ACL (American Cutaneous Leishmaniasis), predominantly caused by L. guyanensis, was mostly efficient in three or two doses of 7 mg/kg[5].

Pentamidine isethionate 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00141037 Kidney Diseases ... 展开 >> Kidney Transplantation Kidney Transplant Renal Transplantation Renal Transplant 收起 << Phase 1 Phase 2 Completed - United States, Alabama ... 展开 >> University of Alabama - Pediatric Nephrology Birmingham, Alabama, United States, 35233 United States, California Maxine Dunitz Children's Health Center Cedars-Sinai Los Angeles, California, United States, 90048 UCLA - Department of Pediatrics, Division of Nephrology Los Angeles, California, United States, 90095-1752 Stanford University Medical Center, Lucile Packard Children's Hospital Palo Alto, California, United States, 94304 UCSF Children's Hospital San Francisco, California, United States, 94143 United States, Florida University of Florida - Pediatric Nephrology Gainesville, Florida, United States, 32610-0296 United States, Louisiana Children's Hospital of New Orleans-Department of Pediatric Nephrology New Orleans, Louisiana, United States, 70118 United States, Massachusetts Children's Hospital Boston - Division of Nephrology Boston, Massachusetts, United States, 02115 United States, Michigan University of Michigan Medical Center, C.S. Mott Children's Hospital- Division of Nephrology & Transplantation Ann Arbor, Michigan, United States, 48109 United States, Missouri Children's Mercy Hospital - Department of Nephrology Kansas City, Missouri, United States, 64108 United States, Pennsylvania The Children's Hospital of Philadelphia-Department of Nephrology Philadelphia, Pennsylvania, United States, 19104 United States, Washington Children's Hospital & Regional Medical Center - Division of Nephrology Seattle, Washington, United States, 98105 收起 <<
NCT00014911 Diabetes Mellitus, Insulin-Dep... 展开 >>endent 收起 << Phase 2 Completed - United States, Florida ... 展开 >> University of Miami Miami, Florida, United States, 33136 United States, Massachusetts Massachusetts General Hospital Boston, Massachusetts, United States, 02114 United States, Minnesota University of Minnesota Minneapolis, Minnesota, United States, 55455 United States, Missouri Washington University St. Louis, Missouri, United States, 63110 United States, Washington Benaroya Research Institute at Virginia Mason Research Center Seattle, Washington, United States, 98101 Canada, Alberta University of Alberta Edmonton, Alberta, Canada Germany Justus-Leibig University Giessen, Germany, 35385 Italy University of Milan Milan, Italy Switzerland University of Geneva Geneva, Switzerland 收起 <<
NCT00141037 - Completed - -

Pentamidine isethionate 参考文献

[1]Nguewa PA, Fuertes MA, et al. Pentamidine is an antiparasitic and apoptotic drug that selectively modifies ubiquitin. Chem Biodivers. 2005 Oct;2(10):1387-400.

[2]Sands M, Kron MA, et al. Pentamidine: a review. Rev Infect Dis. 1985 Sep-Oct;7(5):625-34.

[3]Goa KL, Campoli-Richards DM. Pentamidine isethionate. A review of its antiprotozoal activity, pharmacokinetic properties and therapeutic use in Pneumocystis carinii pneumonia. Drugs. 1987;33(3):242–258

[4]Christen JR, Bourreau E, Demar M, et al. Use of the intramuscular route to administer pentamidine isethionate in Leishmania guyanensis cutaneous leishmaniasis increases the risk of treatment failure. Travel Med Infect Dis. 2018;24:31–36

[5]Gadelha EPN, Ramasawmy R, da Costa Oliveira B, et al. An open label randomized clinical trial comparing the safety and effectiveness of one, two or three weekly pentamidine isethionate doses (seven milligrams per kilogram) in the treatment of cutaneous leishmaniasis in the Amazon Region. PLoS Negl Trop Dis. 2018;12(10):e0006850. Published 2018 Oct 31

Pentamidine isethionate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.69mL

0.34mL

0.17mL

8.44mL

1.69mL

0.84mL

16.87mL

3.37mL

1.69mL

Pentamidine isethionate 技术信息

CAS号140-64-7
分子式C23H36N4O10S2
分子量 592.683
别名 喷他脒羟乙磺酸盐 ;MP-601205 isethionate
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere,Store in freezer, under -20°C
溶解度

DMSO: 105 mg/mL(177.16 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(168.72 mM)，配合低频超声助溶
动物实验配方

Tags: Pentamidine isethionate | MP-601205 isethionate | 喷他脒羟乙磺酸盐 | Insect Repellent | Phosphatase | Antibacterial | AmBeed-信号通路专用抑制剂 | Pentamidine isethionate 纯度/质量文件 | Pentamidine isethionate 生物活性 | Pentamidine isethionate 临床数据 | Pentamidine isethionate 参考文献 | Pentamidine isethionate 实验方案 | Pentamidine isethionate 技术信息

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