贝母素甲 /Peimine
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货号：A403106
同义名：
贝母甲素
/ Verticine;Dihydroisoimperialine
Peimine 可抑制 LPS 诱导的炎性细胞因子产生，并阻断 MAPK 和 NF-κB 信号通路，从川贝母（Fritillaria thunbergii）鳞茎中提取纯化。
Peimine 化学结构
Peimine 3D分子结构
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Peimine 纯度/质量文件 产品仅供科研
货号：A403106
标准纯度：
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Peimine 质控信息
Peimine 生物活性
描述
Peimine is a natural compound with good anti-inflammatory effects in vivo. Peimine (0-25 mg/L) significantly inhibited tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-1β, and increased IL-10 production. Furthermore, peimine significantly inhibited the phosphorylation of p38, ERK and c-jun N-terminal kinase (JNK) as well as decreased p65 and IκB[3] [4] [5] [6]
Peimine 参考文献
[1] Yi PF, Wu YC, et al. Peimine impairs pro-inflammatory cytokine secretion through the inhibition of the activation of NF-κB and MAPK in LPS-induced RAW264.7 macrophages. Immunopharmacol Immunotoxicol. 2013 Oct;35(5):567-72.
[2] Chen L, Liu L, et al. Comparative pharmacokinetic studies of peimine and peiminine in rat plasma by LC-MS-MS after oral administration of Fritillaria thunbergii Miq. and Fritillaria thunbergii Miq. -Glycyrrhiza uralensis Fisch. couple extract. Pharmazie. 2011 Sep;66(9):684-9.
[3] Yi PF, Wu YC, Dong HB, Guo Y, Wei Q, Zhang C, Song Z, Qin QQ, Lv S, Wu SC, Fu BD. Peimine impairs pro-inflammatory cytokine secretion through the inhibition of the activation of NF-κB and MAPK in LPS-induced RAW264.7 macrophages. Immunopharmacol Immunotoxicol. 2013 Oct;35(5):567-72
[4] Park JH, Lee B, Kim HK, Kim EY, Kim JH, Min JH, Kim S, Sohn Y, Jung HS. Peimine Inhibits the Production of Proinflammatory Cytokines Through Regulation of the Phosphorylation of NF-κB and MAPKs in HMC-1 Cells. Pharmacogn Mag. 2017 Jul;13(Suppl 2):S359-S364
[5] Chen Q, Yin C, Li Y, Yang Z, Tian Z. Pharmacokinetic interaction between peimine and paeoniflorin in rats and its potential mechanism. Pharm Biol. 2021 Dec;59(1):129-133
[6] Chen L, Lu X, Liang X, Hong D, Guan Z, Guan Y, Zhu W. Mechanistic studies of the transport of peimine in the Caco-2 cell model. Acta Pharm Sin B. 2016 Mar;6(2):125-31
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Peimine 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.32mL
0.46mL
0.23mL
11.58mL
2.32mL
1.16mL
23.17mL
4.63mL
2.32mL
Peimine 技术信息
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