Peimine can inhibit the production of inflammatory cytokines induced by LPS and block MAPK andNF-κB signaling pathways. It is purified from the bulbus of fritillaria thunbergii.
Peimine is a natural compound with good anti-inflammatory effects in vivo. Peimine (0-25 mg/L) significantly inhibited tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-1β, and increased IL-10 production. Furthermore, peimine significantly inhibited the phosphorylation of p38, ERK and c-jun N-terminal kinase (JNK) as well as decreased p65 and IκB[3]. Moreover, peimine reduced MAPKs (Mitogen-activated protein kinases) phosphorylation and the nuclear NF-κB expression in PMACI-induced HMC-1(human mast cell). Peimine decreased PCA (Passive cutaneous anaphylaxis) reactions in rats as well[4]. Peimine increased the systemic exposure of paeoniflorin through inhibiting the activity of CYP3A4 and P-gp[5]. The intestinal absorption of peimine across Caco-2 cell monolayers involves active transport and that peimine is a substrate of P-gp[6].
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