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Peimine

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Chemical Structure| 23496-41-5 同义名 : 贝母甲素 ;Verticine;Dihydroisoimperialine;5α-Cevane-3β,6α,20-triol;Wanpeinine A
CAS号 : 23496-41-5
货号 : A403106
分子式 : C27H45NO3
纯度 : 98%
分子量 : 431.651
MDL号 : MFCD02259442
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(115.83 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Peimine is a natural compound with good anti-inflammatory effects in vivo. Peimine (0-25 mg/L) significantly inhibited tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-1β, and increased IL-10 production. Furthermore, peimine significantly inhibited the phosphorylation of p38, ERK and c-jun N-terminal kinase (JNK) as well as decreased p65 and IκB[3]. Moreover, peimine reduced MAPKs (Mitogen-activated protein kinases) phosphorylation and the nuclear NF-κB expression in PMACI-induced HMC-1(human mast cell). Peimine decreased PCA (Passive cutaneous anaphylaxis) reactions in rats as well[4]. Peimine increased the systemic exposure of paeoniflorin through inhibiting the activity of CYP3A4 and P-gp[5]. The intestinal absorption of peimine across Caco-2 cell monolayers involves active transport and that peimine is a substrate of P-gp[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.32mL

0.46mL

0.23mL

11.58mL

2.32mL

1.16mL

23.17mL

4.63mL

2.32mL
参考文献

[1]Yi PF, Wu YC, et al. Peimine impairs pro-inflammatory cytokine secretion through the inhibition of the activation of NF-κB and MAPK in LPS-induced RAW264.7 macrophages. Immunopharmacol Immunotoxicol. 2013 Oct;35(5):567-72.

[2]Chen L, Liu L, et al. Comparative pharmacokinetic studies of peimine and peiminine in rat plasma by LC-MS-MS after oral administration of Fritillaria thunbergii Miq. and Fritillaria thunbergii Miq. -Glycyrrhiza uralensis Fisch. couple extract. Pharmazie. 2011 Sep;66(9):684-9.

[3]Yi PF, Wu YC, Dong HB, Guo Y, Wei Q, Zhang C, Song Z, Qin QQ, Lv S, Wu SC, Fu BD. Peimine impairs pro-inflammatory cytokine secretion through the inhibition of the activation of NF-κB and MAPK in LPS-induced RAW264.7 macrophages. Immunopharmacol Immunotoxicol. 2013 Oct;35(5):567-72

[4]Park JH, Lee B, Kim HK, Kim EY, Kim JH, Min JH, Kim S, Sohn Y, Jung HS. Peimine Inhibits the Production of Proinflammatory Cytokines Through Regulation of the Phosphorylation of NF-κB and MAPKs in HMC-1 Cells. Pharmacogn Mag. 2017 Jul;13(Suppl 2):S359-S364

[5]Chen Q, Yin C, Li Y, Yang Z, Tian Z. Pharmacokinetic interaction between peimine and paeoniflorin in rats and its potential mechanism. Pharm Biol. 2021 Dec;59(1):129-133

[6]Chen L, Lu X, Liang X, Hong D, Guan Z, Guan Y, Zhu W. Mechanistic studies of the transport of peimine in the Caco-2 cell model. Acta Pharm Sin B. 2016 Mar;6(2):125-31