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具栖冬青苷 /Pedunculoside {[allProObj[0].p_purity_real_show]}

货号:A457052 同义名: 长梗冬青苷 Ambeed 开学季,买赠积分,赢豪礼

Pedunculoside, a natural product isolated and purified from the barks of Ilex rotunda Thunb., has antiinflammation, heat-clearing, detoxifying, dehumidification, and odynolysis activities.

Pedunculoside 化学结构 CAS号:42719-32-4
Pedunculoside 化学结构
CAS号:42719-32-4
Pedunculoside 3D分子结构
CAS号:42719-32-4
Pedunculoside 化学结构 CAS号:42719-32-4
Pedunculoside 3D分子结构 CAS号:42719-32-4
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Pedunculoside 纯度/质量文件 产品仅供科研

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Pedunculoside 生物活性

描述 Pedunculoside (PE) is a novel triterpene saponin extracted from the dried barks of Ilex rotunda Thunb. Treatment with PE for 7-week (30, 15, or 5 mg/kg daily) dramatically decreased serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) and reduced liver TC in hyperlipidemia rat induced by high-fat diet. Besides, PE-treated group decreased weights and diameters of epididymal adipose hyperlipidemia rat[3]. PE significantly inhibited proliferation and migration of FLSs(fibroblast-like synoviocytes). PE also decreased the production of pro-inflammatory cytokines, including interleukin-1β (IL-1β), IL-6, IL-8, and tumour necrosis factor-α (TNF-α). PE treatment significantly inhibited synovial inflammation and bone destruction in CIA (collagen-induced arthritis) rats[4]. PE had an obvious effect on DSS(dextran sulfate sodium)-induced ulcerative colitis. PE significantly improved the colon length and clinical score in mice, and significantly inhibited the production of inflammatory cytokines. In the LPS-induced inflammatory response of RAW264.7 macrophages, we also found that PE significantly inhibited the phosphorylation of AKT, ERK1/2, JNK1/2, P65, and P38 to reduce the production of IL-1β, IL-6, TNF-α, COX-2, and iNOS. Furthermore, PE suppressed the LPS-induced transcriptional activities of nuclear factor P65 as well as the phosphorylation of P65[5].

Pedunculoside 参考文献

[1]Liu C, Zhang W, et al. A water-soluble inclusion complex of pedunculoside with the polymer β-cyclodextrin: a novel anti-inflammation agent with low toxicity. PLoS One. 2014 Jul 11;9(7):e101761.

[2]Wang C, Chao Z, et al. Enrichment and purification of pedunculoside and syringin from the barks of Ilex rotunda with macroporous resins. J Liq Chromatogr Relat Technol. 2014 Feb 1;37(4):572-587.

[3]Liu C, Shen YJ, Tu QB, Zhao YR, Guo H, Wang J, Zhang L, Shi HW, Sun Y. Pedunculoside, a novel triterpene saponin extracted from Ilex rotunda, ameliorates high-fat diet induced hyperlipidemia in rats. Biomed Pharmacother. 2018 May;101:608-616

[4]Ma X, Chen G, Wang J, Xu J, Zhao F, Hu M, Xu Z, Yang B, Guo J, Sun S, Liu M. Pedunculoside attenuates pathological phenotypes of fibroblast-like synoviocytes and protects against collagen-induced arthritis. Scand J Rheumatol. 2019 Sep;48(5):383-392

[5]Liu K, Li G, Guo W, Zhang J. The protective effect and mechanism of pedunculoside on DSS (dextran sulfate sodium) induced ulcerative colitis in mice. Int Immunopharmacol. 2020 Nov;88:107017

Pedunculoside 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.54mL

0.31mL

0.15mL

7.68mL

1.54mL

0.77mL

15.36mL

3.07mL

1.54mL

Pedunculoside 技术信息

CAS号42719-32-4
分子式C36H58O10
分子量 650.84
别名 长梗冬青苷
运输蓝冰
存储条件

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 105 mg/mL(161.33 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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