Praeruptorin D, a natural product isolated and purified from the roots of Peucedanum praeruptorum Dunn., can significantly inhibit the infiltration of activated polymorphonuclear leukocytes (PMNs) and decrease the levels of TNF-α and IL-6 in bronchoalveolar lavage fluid at the same dose, suppresses LPS induced Nuclear Factor-kappa B (NF-κB) pathway activation in the lung by decreasing the cytoplasmic loss of inhibitor κB-α (IκB-α) protein and inhibiting the translocation of p65 from cytoplasm to nucleus.

FASN-IN-3是一种脂肪酸合酶 (FASN) 抑制剂，具有潜在的抗肿瘤活性。

Denifanstat是一种口服有效的FASN抑制剂，能够抑制脂肪酸合成，对脂肪肝和癌症的研究有显著的应用潜力。

TVB-3166 is an orally-available, reversible, potent, and selective FASN inhibitor.

Ac-CoA Synthase Inhibitor is a reversible inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2) with IC50 of ~ 600 nM.

Isonicotinic acid hydrazide is an antibacterial agent used primarily as a tuberculostatic by blocking the action of fatty acid synthase by interacting with KatG.

UCM05 (G28UCM)是一种有效的脂肪酸合酶 (FASN) 抑制剂，对 HER2+ 乳腺癌具有作用活性，尤其在抗 HER2 耐药细胞系中表现出活性。UCM05 也是一种丝状温度敏感蛋白 Z (FtsZ) 抑制剂，对革兰氏阳性菌 B. subtilis 有效，MIC 值为 100 μM，但对革兰氏阴性菌 E. coli 无效。

Fasnall是一种选择性脂肪酸合成酶 (FASN) 抑制剂，能够有效抑制癌细胞的生长，应用于癌症治疗。

Pedunculoside, a natural product isolated and purified from the barks of Ilex rotunda Thunb., has antiinflammation, heat-clearing, detoxifying, dehumidification, and odynolysis activities.

Agrimol B 是一种多酚类化合物，口服有效的 SIRT1 激活剂。它具有抗脂肪生成和抗癌活性，并对植物病原体表现出抗菌特性。

Desoxyrhaponticin, a natural product isolated and purified from the roots of Rumex obtusifolius L., is an agent that is potentially effective in controlling postprandial hyperglycemia in diabetes, the in vivo antidiabetic action of this compound can be explained, in part at least, by inhibition of glucose transport in the small intestine and inhibition of glucose reabsorption in the kidney, and is considered as promising fatty acid synthase(FAS) inhibitors, they could inhibit intracellular FAS activity and downregulate FAS expression in human breast cancer MCF-7 cells.

Coenzyme A is a coenzyme that plays an important role in the synthesis and oxidation of fatty acids.

Palmitic acid sodium是一种有机化合物，在清洁产品、洗发水和护肤品中常用作表面活性剂和乳化剂，增强它们的稳定性和溶解性。此外，它广泛应用于食品工业，特别是巧克力和油制品中。

FGH10019 is a sterol regulatory element-binding protein (SREBP) inhibitor with IC50 of 1 μM, displaying 5–10 times lower than the IC50 of fatostatin (~10 μM).