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描述 | PF-1355 demonstrates a dose-dependent inhibition of MPO activity in human neutrophils activated by phorbol ester, as indicated by taurine chlorination with an EC50 of 1.47 μM, and in human blood treated with LPS, as shown by the measurement of remaining MPO activity with an EC50 of 2.03 μM[1]. |
Animal study | When administered orally, PF-1355 decreases plasma MPO activity, vascular swelling, neutrophil infiltration, and increases circulating cytokines. In a model of what used to be called Goodpasture disease, now referred to as anti-glomerular basement membrane disease, PF-1355 completely prevents albuminuria and chronic kidney dysfunction[1]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
3.11mL 0.62mL 0.31mL |
15.56mL 3.11mL 1.56mL |
31.12mL 6.22mL 3.11mL |
CAS号 | 1435467-38-1 |
分子式 | C14H15N3O4S |
分子量 | 321.352 |
别名 | PF-06281355 |
运输 | 蓝冰 |
存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 Pure form Sealed in dry,Room Temperature |
溶解方案 |
DMSO: 50 mg/mL(155.59 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO 以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
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动物实验配方 |