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PF-1355

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Chemical Structure| 1435467-38-1 同义名 : PF-06281355
CAS号 : 1435467-38-1
货号 : A286603
分子式 : C14H15N3O4S
纯度 : 99%+
分子量 : 321.352
MDL号 : MFCD29472589
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(155.59 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 PF-1355 demonstrates a dose-dependent inhibition of MPO activity in human neutrophils activated by phorbol ester, as indicated by taurine chlorination with an EC50 of 1.47 μM, and in human blood treated with LPS, as shown by the measurement of remaining MPO activity with an EC50 of 2.03 μM[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.11mL

0.62mL

0.31mL

15.56mL

3.11mL

1.56mL

31.12mL

6.22mL

3.11mL
参考文献

[1]Zheng W, et al. PF-1355, a mechanism-based myeloperoxidase inhibitor, prevents immune complex vasculitis and anti-glomerular basement membrane glomerulonephritis. J Pharmacol Exp Ther. 2015 May;353(2):288-98