PCO371 is an orally active full agonist of parathyroid hormone receptor 1 (PTHR1), shows no effect on PTH type 2 receptor.
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描述 | PCO371, an oral agonist fully targeting PTHR1, does not interact with the PTH type 2 receptor. It prompts cAMP production with an EC50 of 2.4 μM in COS-7 cells with hPTHR1 and 2.5 μM in COS-7 cells with hPTHR1-delNT. Additionally, PCO371 increases phospholipase C activity, with an EC50 of 17 μM[1]. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT02475616 | Healthy | Phase 1 | Terminated | - | United States, California ... 展开 >> Wcct Global Cypress, California, United States 收起 << |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
1.57mL 0.31mL 0.16mL |
7.87mL 1.57mL 0.79mL |
15.73mL 3.15mL 1.57mL |
CAS号 | 1613373-33-3 |
分子式 | C29H32F3N5O6S |
分子量 | 635.654 |
别名 | |
运输 | 蓝冰 |
存储条件 |
粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 105 mg/mL(165.18 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |