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PCO371

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Chemical Structure| 1613373-33-3 同义名 : -
CAS号 : 1613373-33-3
货号 : A362704
分子式 : C29H32F3N5O6S
纯度 : 98%+
分子量 : 635.654
MDL号 : MFCD31657324
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(165.18 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 PCO371, an oral agonist fully targeting PTHR1, does not interact with the PTH type 2 receptor. It prompts cAMP production with an EC50 of 2.4 μM in COS-7 cells with hPTHR1 and 2.5 μM in COS-7 cells with hPTHR1-delNT. Additionally, PCO371 increases phospholipase C activity, with an EC50 of 17 μM[1].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02475616 Healthy Phase 1 Terminated - United States, California ... 展开 >> Wcct Global Cypress, California, United States 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.57mL

0.31mL

0.16mL

7.87mL

1.57mL

0.79mL

15.73mL

3.15mL

1.57mL
参考文献

[1]Tamura T, et al. Identification of an orally active small-molecule PTHR1 agonist for the treatment of hypoparathyroidism. Nat Commun. 2016 Nov 18;7:13384.