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{[ getRatePrice(item.pr_rmb, 1,1) ]} | {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} | 现货 | 咨询 | - + |
快速发货 顺丰冷链运输,1-2 天到达
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产品名称 | NAMPT ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CHS-828 |
+++
NAMPT, IC50: <25 nM NAMPT, Kd: 120 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
STF-118804 | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | P7C3 is an orally bioavailable and blood-brain barrier penetrant aminopropyl carbazole with neuroprotective effects, which can be used for the research of neurodegenerative diseases, including Parkinson's disease[1].[2].[3]. |
体内研究 | Administered at 20 mg/kg/d intraperitoneally twice daily for 21 days, P7C3 suppresses microglial activation and the resulting loss of dopaminergic (DA) neurons in vivo. |
体外研究 | P7C3 inhibits the production of LPS-induced proinflammatory factors in BV2 cells[3]. P7C3 markedly reduces the levels of iNOS and COX-2 in these cells in a dose-responsive manner, without compromising cell health[3]. Furthermore, P7C3 hampers the LPS-induced movement of the NF-κB p65 subunit into the nucleus in BV2 cells, and it inhibits the LPS-driven degradation of inhibitory κB alpha (IκBα) by blocking IκB kinase (IKK) activation[3]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.11mL 0.42mL 0.21mL |
10.54mL 2.11mL 1.05mL |
21.09mL 4.22mL 2.11mL |
CAS号 | 301353-96-8 |
分子式 | C21H18Br2N2O |
分子量 | 474.188 |
别名 | |
运输 | 蓝冰 |
存储条件 |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 35 mg/mL(73.81 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |