产品说明书

P7C3

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Chemical Structure| 301353-96-8 同义名 : -
CAS号 : 301353-96-8
货号 : A176049
分子式 : C21H18Br2N2O
纯度 : 99%
分子量 : 474.188
MDL号 : MFCD00572918
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 35 mg/mL(73.81 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 P7C3 is an orally bioavailable and blood-brain barrier penetrant aminopropyl carbazole with neuroprotective effects, which can be used for the research of neurodegenerative diseases, including Parkinson's disease[1].[2].[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.11mL

0.42mL

0.21mL

10.54mL

2.11mL

1.05mL

21.09mL

4.22mL

2.11mL
参考文献

[1]Pieper AA et al. Discovery of a proneurogenic, neuroprotective chemical. Cell. 2010 Jul 9;142(1):39-51.

[2]Pieper AA et al. P7C3 and an unbiased approach to drug discovery for neurodegenerative diseases. Chem Soc Rev. 2014 Oct 7;43(19):6716-26.

[3]Chao Gu , et al. P7C3 Inhibits LPS-Induced Microglial Activation to Protect Dopaminergic Neurons Against Inflammatory Factor-Induced Cell Death in vitro and in vivo. Front Cell Neurosci. 2018; 12: 400.