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奥硝唑 /Ornidazole {[allProObj[0].p_purity_real_show]}

货号：A213162 同义名： Ro 7-0207;NSC 95075

Ornidazole is an antibiotic used to treat some protozoan infections and investigated for use in Crohn's disease after bowel resection.

Ornidazole 化学结构 CAS号：16773-42-5
Ornidazole 化学结构
CAS号：16773-42-5
Ornidazole 3D分子结构
CAS号：16773-42-5
Ornidazole 化学结构 CAS号：16773-42-5
Ornidazole 3D分子结构 CAS号：16773-42-5
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Ornidazole 纯度/质量文件 产品仅供科研

货号：A213162 标准纯度： {[allProObj[0].p_purity_real_show]}
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Ornidazole 生物活性

描述 Ornidazole is a 5-nitroimidazole derivative with antiprotozoal and antibacterial properties against anaerobic bacteria. Ornidazole 1 g/day is effective for the prevention of recurrence of Crohn's disease after ileocolonic resection[3]. Adverse effects on the central nervous system (CNS) are the main side effects of ornidazole during its clinical application[4]. A concentration of 3. 1 mg/mL of ornidazole inhibited 98% of the strains of B. fragilis, with greater sensitivity when ampicillin and gentamicin were also present. A concentration of 6. 2 mg/mL of ornidazole inhibited 16 of 18 strains of C. perfringens and all 11 strains of other Clostridium species[5]. Moreover, ornidazole loaded fibers could be a potential drug delivery system for the treatment of gingivitis[6].

Ornidazole 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01662765 - Completed - -
NCT00609973 Crohn's Disease Phase 2 Completed - United States, North Carolina ... 展开 >> University of North Carolina Chapel Hill, North Carolina, United States, 27599 收起 <<
NCT01662765 Pilonidal Sinus ... 展开 >> Sinus; Dermal, Pilonidal Umbilical Granuloma 收起 << Not Applicable Completed - Turkey ... 展开 >> Hatem Hospital Gaziantep, Turkey, 27090 Medical Park Gaziantep Hospital Gaziantep, Turkey, 27090 25 Aralık Familiy Physician Health Center Gaziantep, Turkey, 27100 Dr.Ersin Arslan State Hospital Gaziantep, Turkey, 27100 Şehitkamil State Hospital Gaziantep, Turkey, 27100 收起 <<

Ornidazole 参考文献

[1]Rutgeerts P, Van Assche G, et al. Ornidazole for prophylaxis of postoperative Crohn's disease recurrence: a randomized, double-blind, placebo-controlled trial. Gastroenterology. 2005 Apr;128(4):856-61.

[2]Goldstein EJ, Sutter VL, Finegold SM. Comparative susceptibilities of anaerobic bacteria to metronidazole, ornidazole, and SC-28538. Antimicrob Agents Chemother. 1978 Oct;14(4):609-13.

[3]Rutgeerts P, Van Assche G, Vermeire S, D'Haens G, Baert F, Noman M, Aerden I, De Hertogh G, Geboes K, Hiele M, D'Hoore A, Penninckx F. Ornidazole for prophylaxis of postoperative Crohn's disease recurrence: a randomized, double-blind, placebo-controlled trial. Gastroenterology. 2005 Apr;128(4):856-61. doi: 10.1053/j.gastro.2005.01.010. PMID: 15825069.

[4]Wei TT, Sun JH, Han LW, Chen K, Wang ZQ, Ji H. Effects of the ornidazole enantiomers on the central nervous system: Involvement of the GABAA receptor. Chem Biol Interact. 2015 Dec 5;242:163-9. doi: 10.1016/j.cbi.2015.09.019. Epub 2015 Sep 26. PMID: 26415617.

[5]Palmu A, Renkonen OV, Aromaa U. Ornidazole and anaerobic bacteria: in vitro sensitivity and effects on wound infections after appendectomy. J Infect Dis. 1979 May;139(5):586-9. doi: 10.1093/infdis/139.5.586. PMID: 220342.

[6]Tort S, Yıldız A, Tuğcu-Demiröz F, Akca G, Kuzukıran Ö, Acartürk F. Development and characterization of rapid dissolving ornidazole loaded PVP electrospun fibers. Pharm Dev Technol. 2019 Sep;24(7):864-873. doi: 10.1080/10837450.2019.1615088. Epub 2019 Jun 7. PMID: 31046546.

Ornidazole 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.55mL

0.91mL

0.46mL

22.77mL

4.55mL

2.28mL

45.53mL

9.11mL

4.55mL

Ornidazole 技术信息

CAS号16773-42-5
分子式C7H10ClN3O3
分子量 219.626
别名 Ro 7-0207;NSC 95075;Tiberal;(±)-Ornidazole
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Room Temperature
溶解度

DMSO: 105 mg/mL(478.09 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 10 mg/mL(45.53 mM)，配合低频超声助溶
动物实验配方

Tags: Ornidazole | 16773-42-5 | Ro 7-0207 | Anti-infection | Bacterial | Parasite | Antibiotic | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Ornidazole 纯度/质量文件 | Ornidazole 生物活性 | Ornidazole 临床数据 | Ornidazole 参考文献 | Ornidazole 实验方案 | Ornidazole 技术信息

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