产品说明书
Ornidazole
 |
同义名 : | Ro 7-0207;NSC 95075;Tiberal;(±)-Ornidazole |
| CAS号 : | 16773-42-5 | |
| 货号 : | A213162 | |
| 分子式 : | C7H10ClN3O3 | |
| 纯度 : | 98% | |
| 分子量 : | 219.626 | |
| MDL号 : | MFCD00057960 | |
| 存储条件： |
粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(478.09 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 10 mg/mL(45.53 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Ornidazole is a 5-nitroimidazole derivative with antiprotozoal and antibacterial properties against anaerobic bacteria. Ornidazole 1 g/day is effective for the prevention of recurrence of Crohn's disease after ileocolonic resection[3]. Adverse effects on the central nervous system (CNS) are the main side effects of ornidazole during its clinical application[4]. A concentration of 3. 1 mg/mL of ornidazole inhibited 98% of the strains of B. fragilis, with greater sensitivity when ampicillin and gentamicin were also present. A concentration of 6. 2 mg/mL of ornidazole inhibited 16 of 18 strains of C. perfringens and all 11 strains of other Clostridium species[5]. Moreover, ornidazole loaded fibers could be a potential drug delivery system for the treatment of gingivitis[6]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT01662765 | - | Completed | - | - | |
| NCT00609973 | Crohn's Disease | Phase 2 | Completed | - | United States, North Carolina ... 展开 >> University of North Carolina Chapel Hill, North Carolina, United States, 27599 收起 << |
| NCT01662765 | Pilonidal Sinus ... 展开 >> Sinus; Dermal, Pilonidal Umbilical Granuloma 收起 << | Not Applicable | Completed | - | Turkey ... 展开 >> Hatem Hospital Gaziantep, Turkey, 27090 Medical Park Gaziantep Hospital Gaziantep, Turkey, 27090 25 Aralık Familiy Physician Health Center Gaziantep, Turkey, 27100 Dr.Ersin Arslan State Hospital Gaziantep, Turkey, 27100 Şehitkamil State Hospital Gaziantep, Turkey, 27100 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
4.55mL 0.91mL 0.46mL |
22.77mL 4.55mL 2.28mL |
45.53mL 9.11mL 4.55mL |
| 参考文献 |
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