Sakakin, a natural product isolated and purified from the rhizomes of Curculigo orchioides Gaertn, can improve depressive behaviour in chronic unpredictable mild stress (CUMS) rats by downregulating HPA axis hyperactivity and increasing BDNF expression and ERK1/2 phosphorylation in the hippocampus.
Sakakin (Orcinol glucoside, OG) is an active constituent isolated from the rhizomes of Curculigo orchioides Gaertn. It shows potent antioxidative and anxiolytic activities without sedative effects. OG (5, 10, and 20 mg/kg) increased the time spent in open arms and the number of entries into open arms in the elevated plus-maze test. OG (5 and 10 mg/kg) increased the number of head-dips in the hole-board test. At all tested doses, OG does not significantly affect the locomotion of mice in the open-field test. OG is anxiolytic agents without sedative effects[3]. OG prevented bone loss by stimulating bone formation and attenuating fat formation in bone. In vitro, OG promoted osteoblastic differentiation and inhibited adipogenic differentiation of BMSCs. Inhibition of Wnt/β-catenin by ICG-001 significantly reversed the effect of OG on osteogenic and adipogenic differentiation of BMSCs(bone mesenchymal stem cells)[4].
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