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Orcinol glucoside

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Chemical Structure| 21082-33-7 同义名 : Sakakin
CAS号 : 21082-33-7
货号 : A276822
分子式 : C13H18O7
纯度 : 98%
分子量 : 286.278
MDL号 : MFCD06794970
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(419.17 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Sakakin (Orcinol glucoside, OG) is an active constituent isolated from the rhizomes of Curculigo orchioides Gaertn. It shows potent antioxidative and anxiolytic activities without sedative effects. OG (5, 10, and 20 mg/kg) increased the time spent in open arms and the number of entries into open arms in the elevated plus-maze test. OG (5 and 10 mg/kg) increased the number of head-dips in the hole-board test. At all tested doses, OG does not significantly affect the locomotion of mice in the open-field test. OG is anxiolytic agents without sedative effects[3]. OG prevented bone loss by stimulating bone formation and attenuating fat formation in bone. In vitro, OG promoted osteoblastic differentiation and inhibited adipogenic differentiation of BMSCs. Inhibition of Wnt/β-catenin by ICG-001 significantly reversed the effect of OG on osteogenic and adipogenic differentiation of BMSCs(bone mesenchymal stem cells)[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.49mL

0.70mL

0.35mL

17.47mL

3.49mL

1.75mL

34.93mL

6.99mL

3.49mL
参考文献

[1]Wang X, Li G, et al. Anxiolytic effects of orcinol glucoside and orcinol monohydrate in mice. Pharm Biol. 2015 Jun;53(6):876-81.

[2]Ge JF, Gao WC, et al. Orcinol glucoside produces antidepressant effects by blocking the behavioural and neuronal deficits caused by chronic stress. Eur Neuropsychopharmacol. 2014 Jan;24(1):172-80.

[3]Wang X, Li G, Li P, Huang L, Huang J, Zhai H. Anxiolytic effects of orcinol glucoside and orcinol monohydrate in mice. Pharm Biol. 2015 Jun;53(6):876-81

[4]Zhou X, Liu Z, Huang B, Yan H, Yang C, Li Q, Jin D. Orcinol glucoside facilitates the shift of MSC fate to osteoblast and prevents adipogenesis via Wnt/β-catenin signaling pathway. Drug Des Devel Ther. 2019 Aug 5;13:2703-2713