黄柏酮 /Obacunone
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货号：A315545
同义名：
AI3-37934;CCRIS 8657
Obacunone 是一种从黄柏树皮中提取的天然三萜类化合物，具有抗肿瘤活性，并能够通过抑制芳香化酶和炎症通路来预防雌激素依赖型乳腺癌，IC50为28.04 μM。
Obacunone 化学结构
Obacunone 3D分子结构
规格
价格
会员价
库存
数量
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Obacunone 纯度/质量文件 产品仅供科研
货号：A315545
标准纯度：
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产品说明书
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Obacunone 质控信息
Obacunone
+
Nrf2
98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
Obacunone 生物活性
靶点
Aromatase
Aromatase, IC50:28.4 μM
描述
Obacunone belongs to a class of unique triterpenoids called limonoids, present in Citrus species. Obacunone possesses antivirulence activity and demonstrates inhibition of cell-cell signaling in Vibrio harveyi and Escherichia coli O157:H7[3] [4] [5]
Obacunone 参考文献
[1] Murthy KN, Jayaprakasha GK, Patil BS. Cytotoxicity of obacunone and obacunone glucoside in human prostate cancer cells involves Akt-mediated programmed cell death. Toxicology. 2015 Mar 2;329:88-97.
[2] Kim J, Jayaprakasha GK, Patil BS. Obacunone exhibits anti-proliferative and anti-aromatase activity in vitro by inhibiting the p38 MAPK signaling pathway in MCF-7 human breast adenocarcinoma cells. Biochimie. 2014 Oct;105:36-44.
[3] Vikram A, Jayaprakasha GK, Jesudhasan PR, Pillai SD, Patil BS. Obacunone represses Salmonella pathogenicity islands 1 and 2 in an envZ-dependent fashion. Appl Environ Microbiol. 2012;78(19):7012-7022
[4] Chidambara Murthy KN, Jayaprakasha GK, Patil BS. Obacunone and obacunone glucoside inhibit human colon cancer (SW480) cells by the induction of apoptosis. Food Chem Toxicol. 2011;49(7):1616-1625
[5] Horiba T, Katsukawa M, Mita M, Sato R. Dietary obacunone supplementation stimulates muscle hypertrophy, and suppresses hyperglycemia and obesity through the TGR5 and PPARγ pathway. Biochem Biophys Res Commun. 2015;463(4):846-852
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Obacunone 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.20mL
0.44mL
0.22mL
11.00mL
2.20mL
1.10mL
22.00mL
4.40mL
2.20mL
Obacunone 技术信息
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