Nafamostat mesylate (FUT-175), a synthetic serine protease inhibitor, functions as an anticoagulant and exhibits both anticancer and antiviral effects. It is known to induce apoptosis by up-regulating the expression of tumor necrosis factor receptor-1 (TNFR1), and it is also used in studies related to the pathological thickening of arterial walls[1].[2].
体内研究
In an in vivo setting, Nafamostat mesylate administered at a dose of 10 mg/kg through intraperitoneal injection once daily for 18 days demonstrates favorable antiviral properties against Zika virus (ZIKV) infection in A129 mice[3].
Additionally, when given at dosages between 0.5 and 2.0 mg/mL (dissolved in saline) via intraperitoneal injection daily for seven consecutive days, it effectively inhibits neointimal formation after balloon injury of the rat carotid wall[4].
体外研究
In laboratory studies, Nafamostat mesylate at concentrations ranging from 10 to 80 μg/mL over durations of 3 to 48 hours inhibits NF-κB activity by blocking the phosphorylation of IκBα in MDAPanc-28 cells[1].
When applied at 80 μg/mL for 24 to 48 hours, it induces apoptosis in these cells by up-regulating TNFR1[1].
Furthermore, Nafamostat mesylate has shown effectiveness in reducing the invasiveness of Panc-1 cells at concentrations from 0.1 to 10 μM over a 24-hour period[2].
Korea, Republic of
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National Health Insurance Corporation Ilsan Hospital
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Koyang, Korea, Republic of
Contact: Tae Ik Chang, MD 82-31-900-0246 tichang@hanmail.net
Seoul National University Bundang Hospital
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Seongnam, Korea, Republic of
Contact: Sejoong Kim, MD, PhD 82-11-9196-5245 imsejoong@hanmail.net
Seoul National University Boramae Medical Center
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Seoul, Korea, Republic of
Contact: Jung Pyo Lee, MD, PhD 82-2-870-2261 kjwa1@medimail.co.kr
Seoul National University Hospital
Recruiting
Seoul, Korea, Republic of
Contact: Su Mi Lee 82-2-2072-1705 promise131@hanmail.net 收起 <<
Korea, Republic of
... 展开 >>
National Health Insurance Corporation Ilsan Hospital
Recruiting
Koyang, Korea, Republic of
Contact: Tae Ik Chang, MD 82-31-900-0246 tichang@hanmail.net
Seoul National University Bundang Hospital
Recruiting
Seongnam, Korea, Republic of
Contact: Sejoong Kim, MD, PhD 82-11-9196-5245 imsejoong@hanmail.net
Seoul National University Boramae Medical Center
Recruiting
Seoul, Korea, Republic of
Contact: Jung Pyo Lee, MD, PhD 82-2-870-2261 kjwa1@medimail.co.kr
Seoul National University Hospital
Recruiting
Seoul, Korea, Republic of
Contact: Su Mi Lee 82-2-2072-1705 promise131@hanmail.net 收起 <<
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