产品说明书
Nafamostat Mesylate
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同义名 : | FUT-175;Nafamostat (mesylate);Nafamastat;Coahibitor;Nafamostat mesilate |
| CAS号 : | 82956-11-4 | |
| 货号 : | A570309 | |
| 分子式 : | C21H25N5O8S2 | |
| 纯度 : | 98% | |
| 分子量 : | 539.582 | |
| MDL号 : | MFCD00941430 | |
| 存储条件： |
粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 50 mg/mL(92.66 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 30 mg/mL(55.6 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Nafamostat mesylate (FUT-175), a synthetic serine protease inhibitor, functions as an anticoagulant and exhibits both anticancer and antiviral effects. It is known to induce apoptosis by up-regulating the expression of tumor necrosis factor receptor-1 (TNFR1), and it is also used in studies related to the pathological thickening of arterial walls[1].[2]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT01486485 | Acute Kidney Injury | Phase 3 | Unknown | August 2013 | Korea, Republic of ... 展开 >> National Health Insurance Corporation Ilsan Hospital Recruiting Koyang, Korea, Republic of Contact: Tae Ik Chang, MD 82-31-900-0246 tichang@hanmail.net Seoul National University Bundang Hospital Recruiting Seongnam, Korea, Republic of Contact: Sejoong Kim, MD, PhD 82-11-9196-5245 imsejoong@hanmail.net Seoul National University Boramae Medical Center Recruiting Seoul, Korea, Republic of Contact: Jung Pyo Lee, MD, PhD 82-2-870-2261 kjwa1@medimail.co.kr Seoul National University Hospital Recruiting Seoul, Korea, Republic of Contact: Su Mi Lee 82-2-2072-1705 promise131@hanmail.net 收起 << |
| NCT01001403 | Liver Transplantation ... 展开 >> Postreperfusion Syndrome 收起 << | Phase 4 | Completed | - | Korea, Republic of ... 展开 >> Seoul National University Hospital Seoul, Korea, Republic of, 110-744 收起 << |
| NCT01761994 | Acute Kidney Injury | Phase 4 | Completed | - | Korea, Republic of ... 展开 >> Severance Hospital Seoul, Korea, Republic of, 120-752 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
1.85mL 0.37mL 0.19mL |
9.27mL 1.85mL 0.93mL |
18.53mL 3.71mL 1.85mL |
| 参考文献 |
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