Momordin Ic, a natural product isolated and purified from the fruits of Kochia scoparia (L.) Schrad., might represent a potential source of anticancer candidate, by inducing apoptosis through oxidative stress-regulated mitochondrial dysfunction involving the MAPK and PI3K-mediated iNOS and HO-1 pathways.
Momordin Ic (MI), a natural product isolated and purified from the fruits of Kochia scoparia (L.) Schrad., might represent a potential source of anticancer candidate, by inducing apoptosis through oxidative stress-regulated mitochondrial dysfunction involving the MAPK and PI3K-mediated iNOS and HO-1 pathways. Momordin Ic promoted the formation of autophagic vacuole and expression of Beclin 1 and LC-3 in a dose- and time-dependent manner[3]. Momordin Ic prevent cell invasion by inhibiting VCAM-1, ICAM-1, MMP-9 but inducing E-cadherin expression via p38 and JNK pathways[4]. MI inhibited cell proliferation with G0/1 phase cell cycle arrest in colon cancer cells. MI exerted an anti-tumor activity in colon cancer cells via SENP1/c-Myc signaling pathway[5]. MI, a new type of SENP1 inhibitor, reduces LPS-induced cellular inflammation by depressing SENP1 expression. Furthermore, MI-depressed Sp3 expression disturbed Sp3-nuclear factor (NF)-κB interaction and then alleviated LPS-induced cellular inflammation[6]. Momordin Ic, but not 20-hydroxyecdysone and oleanolic acid, had inhibitory effects on the production of inflammatory cytokines TNF-α and IL-6 in LPS-treated RAW264.7 macrophages[7].
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