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Momordin Ic

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Chemical Structure| 96990-18-0 同义名 : -
CAS号 : 96990-18-0
货号 : A829165
分子式 : C41H64O13
纯度 : 95%
分子量 : 764.939
MDL号 : MFCD11042256
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(137.27 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Momordin Ic (MI), a natural product isolated and purified from the fruits of Kochia scoparia (L.) Schrad., might represent a potential source of anticancer candidate, by inducing apoptosis through oxidative stress-regulated mitochondrial dysfunction involving the MAPK and PI3K-mediated iNOS and HO-1 pathways. Momordin Ic promoted the formation of autophagic vacuole and expression of Beclin 1 and LC-3 in a dose- and time-dependent manner[3]. Momordin Ic prevent cell invasion by inhibiting VCAM-1, ICAM-1, MMP-9 but inducing E-cadherin expression via p38 and JNK pathways[4]. MI inhibited cell proliferation with G0/1 phase cell cycle arrest in colon cancer cells. MI exerted an anti-tumor activity in colon cancer cells via SENP1/c-Myc signaling pathway[5]. MI, a new type of SENP1 inhibitor, reduces LPS-induced cellular inflammation by depressing SENP1 expression. Furthermore, MI-depressed Sp3 expression disturbed Sp3-nuclear factor (NF)-κB interaction and then alleviated LPS-induced cellular inflammation[6]. Momordin Ic, but not 20-hydroxyecdysone and oleanolic acid, had inhibitory effects on the production of inflammatory cytokines TNF-α and IL-6 in LPS-treated RAW264.7 macrophages[7].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.31mL

0.26mL

0.13mL

6.54mL

1.31mL

0.65mL

13.07mL

2.61mL

1.31mL
参考文献

[1]Wang J, Yuan L, et al. Momordin Ic induces HepG2 cell apoptosis through MAPK and PI3K/Akt-mediated mitochondrial pathways. Apoptosis. 2013 Jun;18(6):751-65.

[2]Kim NY, Lee MK, et al. Momordin Ic and oleanolic acid from Kochiae Fructus reduce carbon tetrachloride-induced hepatotoxicity in rats. J Med Food. 2005 Summer;8(2):177-83.

[3]Mi Y, Xiao C, Du Q, Wu W, Qi G, Liu X. Momordin Ic couples apoptosis with autophagy in human hepatoblastoma cancer cells by reactive oxygen species (ROS)-mediated PI3K/Akt and MAPK signaling pathways. Free Radic Biol Med. 2016 Jan;90:230-42

[4]Wang J, Liu Q, Xiao H, Luo X, Liu X. Suppressive effects of Momordin Ic on HepG2 cell migration and invasion by regulating MMP-9 and adhesion molecules: Involvement of p38 and JNK pathways. Toxicol In Vitro. 2019 Apr;56:75-83

[5]Xianjun F, Xirui X, Jie T, Huiwen M, Shaojun Z, Qiaoyun L, Yunxin L, Xuqun S. Momordin Ic induces G0/1 phase arrest and apoptosis in colon cancer cells by suppressing SENP1/c-MYC signaling pathway. J Pharmacol Sci. 2021 Aug;146(4):249-258

[6]Zheng C, Li D, Zhan W, He K, Yang H. Downregulation of SENP1 suppresses LPS-induced macrophage inflammation by elevating Sp3 SUMOylation and disturbing Sp3-NF-κB interaction. Am J Transl Res. 2020 Nov 15;12(11):7439-7448

[7]Yoo SR, Jeong SJ, Lee NR, Shin HK, Seo CS. Quantification Analysis and In Vitro Anti-Inflammatory Effects of 20-Hydroxyecdysone, Momordin Ic, and Oleanolic Acid from the Fructus of Kochia scoparia. Pharmacogn Mag. 2017 Jul-Sep;13(51):339-344