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/ Minoxidil

敏乐啶 /Minoxidil {[allProObj[0].p_purity_real_show]}

货号：A141385 同义名： 米诺地尔 / U10858;Loniten

Minoxidil is an antihypertensive vasodilator medication.

Minoxidil 化学结构 CAS号：38304-91-5
Minoxidil 化学结构
CAS号：38304-91-5
Minoxidil 3D分子结构
CAS号：38304-91-5
Minoxidil 化学结构 CAS号：38304-91-5
Minoxidil 3D分子结构 CAS号：38304-91-5
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Minoxidil 纯度/质量文件 产品仅供科研

货号：A141385 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 Potassium Channel ↓ 其他靶点 纯度
Tolbutamide ✔ 98%
Glimepiride ++++

SUR2B, IC50: 7.3 nM

SUR1, IC50: 5.4 nM

 		97%
Dronedarone Hydrochloride ✔ 95%
Gliquidone ++

Potassium channel, IC50: 27.2 nM

 		98%
TRAM-34 +++

IKCa1 (KCa3.1), Kd: 20 nM

 		98%
Glibenclamide ✔ 98%
Amiodarone HCl ✔ 97%
Gliclazide ++

Potassium channel, IC50: 184 nM

 		98%
Repaglinide ✔ 98%
Dofetilide ✔ 98%
Nateglinide ✔ 99%
Quinine hydrochloride dihydrate ✔ 98%
ML133 HCl +

Kir2.1, IC50: 290 nM

 		97%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Minoxidil 生物活性

描述 Minoxidil (U10858) is an ATP-sensitive potassium (KATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil is also a potent inhibitor of soybean lipoxygenaseare with an IC50 of 20 μM. Minoxidil (0.01 mmoL/kg body weight; intraperitoneal injection; for 3.5 hours; fisher 344 rats) treatment inhibits carrageenan-induced rat paw oedema with an inhibitory potency (49%)[3]. Minoxidil induces generalized hypertrichosis when administered systemically, or localized hair regrowth when applied topically to sites of severe alopecia areata. In the presence of minoxidil, cultures showed a marked dose-dependent second peak of DNA synthesis 8-10 days after culture initiation in epidermal cells. In addition, two morphologically distinct cell types appeared[4]. Minoxidil is a potassium channel opener, causing hyperpolarization of cell membranes and it is also a vasodilator, by widening blood vessels and opening potassium channels, it allows more oxygen, blood and nutrients to the follicle. This can also cause follicles in the telogen phase to shed, usually soon to be replaced by new, thicker hairs in a new anagen phase. The most common adverse reactions of the topical formulation are limited to irritant and allergic contact dermatitis on the scalp[5].

Minoxidil 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00283686 Kidney, Polycystic Phase 3 Completed - United States, Colorado ... 展开 >> University of Colorado Health Sciences Center Denver (Aurora), Colorado, United States, 800045 United States, Georgia Emory University School of Medicine Atlanta, Georgia, United States, 30322 United States, Kansas University of Kansas Medical Center Kansas City, Kansas, United States, 66160 United States, Massachusetts Tufts University-New England Medical Center Boston, Massachusetts, United States, 02111 Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 United States, Ohio Cleveland Clinic Foundation Cleveland, Ohio, United States, 44195 收起 <<
NCT00283686 - Completed - -
NCT01227031 - Unknown July 2011 Taiwan ... 展开 >> Taipei Medical University-Wan Fang Hospital Not yet recruiting Taipei, Taiwan Contact: Ren-Yu Tsai    886-2-29307930 ext 2980    b671022@tmu.edu.tw 收起 <<

Minoxidil 参考文献

[1]Grice JE, Ciotti S, et al. Relative uptake of minoxidil into appendages and stratum corneum and permeation through human skin in vitro. J Pharm Sci. 2010 Feb;99(2):712-8.

[2]Grice JE, Ciotti S, et al. Relative uptake of minoxidil into appendages and stratum corneum and permeation through human skin in vitro. J Pharm Sci. 2010 Feb;99(2):712-8.

[3]Hadjipavlou-Litina D, Magoulas GE, Bariamis SE, et al. Synthesis and evaluation of the antioxidative potential of minoxidil-polyamine conjugates. Biochimie. 2013;95(7):1437-1449

[4]Cohen RL, Alves ME, Weiss VC, West DP, Chambers DA. Direct effects of minoxidil on epidermal cells in culture. J Invest Dermatol. 1984;82(1):90-93

[5]Rossi A, Cantisani C, Melis L, Iorio A, Scali E, Calvieri S. Minoxidil use in dermatology, side effects and recent patents. Recent Pat Inflamm Allergy Drug Discov. 2012;6(2):130-136

Minoxidil 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.78mL

0.96mL

0.48mL

23.89mL

4.78mL

2.39mL

47.79mL

9.56mL

4.78mL

Minoxidil 技术信息

CAS号38304-91-5
分子式C9H15N5O
分子量 209.25
别名 米诺地尔 ;U10858;Loniten;Minoxidil, Loniten, Rogaine, U 10858
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Room temperature
溶解度

DMSO: 10 mg/mL(47.79 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 1 mg/mL(4.78 mM)，配合低频超声，并水浴加热至45℃助溶

无水乙醇: 7 mg/mL(33.45 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇
动物实验配方

Tags: Minoxidil | U10858;Loniten;Minoxidil, Loniten, Rogaine, U 10858 | 米诺地尔 | Depressurization | Other Compounds | Potassium Channel | AmBeed-信号通路专用抑制剂 | Minoxidil 纯度/质量文件 | Minoxidil 亚型比较 | Minoxidil 生物活性 | Minoxidil 临床数据 | Minoxidil 参考文献 | Minoxidil 实验方案 | Minoxidil 技术信息

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