Minoxidil (U10858) is an ATP-sensitive potassium (KATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil is also a potent inhibitor of soybean lipoxygenaseare with an IC50 of 20 μM. Minoxidil (0.01 mmoL/kg body weight; intraperitoneal injection; for 3.5 hours; fisher 344 rats) treatment inhibits carrageenan-induced rat paw oedema with an inhibitory potency (49%)[3]. Minoxidil induces generalized hypertrichosis when administered systemically, or localized hair regrowth when applied topically to sites of severe alopecia areata. In the presence of minoxidil, cultures showed a marked dose-dependent second peak of DNA synthesis 8-10 days after culture initiation in epidermal cells. In addition, two morphologically distinct cell types appeared[4]. Minoxidil is a potassium channel opener, causing hyperpolarization of cell membranes and it is also a vasodilator, by widening blood vessels and opening potassium channels, it allows more oxygen, blood and nutrients to the follicle. This can also cause follicles in the telogen phase to shed, usually soon to be replaced by new, thicker hairs in a new anagen phase. The most common adverse reactions of the topical formulation are limited to irritant and allergic contact dermatitis on the scalp[5].
United States, Colorado
... 展开 >>
University of Colorado Health Sciences Center
Denver (Aurora), Colorado, United States, 800045
United States, Georgia
Emory University School of Medicine
Atlanta, Georgia, United States, 30322
United States, Kansas
University of Kansas Medical Center
Kansas City, Kansas, United States, 66160
United States, Massachusetts
Tufts University-New England Medical Center
Boston, Massachusetts, United States, 02111
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02215
United States, Minnesota
Mayo Clinic
Rochester, Minnesota, United States, 55905
United States, Ohio
Cleveland Clinic Foundation
Cleveland, Ohio, United States, 44195 收起 <<
United States, Colorado
... 展开 >>
University of Colorado Health Sciences Center
Denver (Aurora), Colorado, United States, 800045
United States, Georgia
Emory University School of Medicine
Atlanta, Georgia, United States, 30322
United States, Kansas
University of Kansas Medical Center
Kansas City, Kansas, United States, 66160
United States, Massachusetts
Tufts University-New England Medical Center
Boston, Massachusetts, United States, 02111
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02215
United States, Minnesota
Mayo Clinic
Rochester, Minnesota, United States, 55905
United States, Ohio
Cleveland Clinic Foundation
Cleveland, Ohio, United States, 44195 收起 <<
United States, Alabama
... 展开 >>
Radiant Research, Inc.
Birmingham, Alabama, United States, 35209
United States, Arizona
Radiant Research, Inc.
Tucson, Arizona, United States, 85710
United States, Florida
Radiant Research, Inc.
Pinellas Park, Florida, United States, 33781
United States, Missouri
Radiant Research, Inc.
St Louis, Missouri, United States, 63141 收起 <<
United States, California
... 展开 >>
Therapeutics Clinical Research
San Diego, California, United States, 92123
United States, Minnesota
Minnesota Clinical Study Center
Fridley, Minnesota, United States, 55432
United States, Texas
DermResearch, Inc.
Austin, Texas, United States, 78759 收起 <<
Canada, British Columbia
... 展开 >>
The Skin Care Centre
Recruiting
Vancouver, British Columbia, Canada, V5Z 4E8
Principal Investigator: Jerry Shapiro, MD FRCPC 收起 <<
United States, California
... 展开 >>
Axis Clinical Trials
Los Angeles, California, United States, 90036
Axis Clinical Trials
Los Angeles, California, United States, 90057
Therapeutics Clinical Research
San Diego, California, United States, 92123
United States, Kansas
Heartland Research Associates LLC
Wichita, Kansas, United States, 67207
United States, Maryland
Callender Skin & Laser Center
Glenn Dale, Maryland, United States, 20769
United States, Michigan
Michigan Center for Skin Care Research
Clinton Township, Michigan, United States, 48038
United States, Minnesota
Minnesota Clinical Study Center
Fridley, Minnesota, United States, 55432
United States, New York
New York University School of Medicine
New York, New York, United States, 10016
Derm Research Center of New York
Stony Brook, New York, United States, 11790
United States, Ohio
Cleveland Clinic
Cleveland, Ohio, United States, 44195
United States, Texas
J&S Studies, Inc.
College Station, Texas, United States, 77845
David A. Whiting, MD PA
Dallas, Texas, United States, 75246
United States, Virginia
The Education & Research Foundation Inc
Lynchburg, Virginia, United States, 24501
France
Hôpital Saint Jacques Service de Dermatologie
Besançon, France, 25030
Germany
Clinical Research Center for Hair and Skin Science Universitätsmedizin Berlin
Berlin, Germany, 10117
Dermaticum Practice for Dermatology
Freiburg, Germany, 79098
United Kingdom
George Eliot Hospital
Nuneaton, United Kingdom, CV10 7DJ 收起 <<
France
... 展开 >> Service de Cardiologie Pédiatrique, CHU Angers
Angers, France, 49033
Service de Cardiologie, Hôpital Saint-André, CHU Bordeaux
Bordeaux, France, 33075
Service de Néphrologie Pédiatrique, Hôpital Pellegrin, CHU Bordeaux
Bordeaux, France, 33076
Service de Génétique Médicale, Hôpital Pellegrin, CHU Bordeaux
Bordeaux, France
Département de Pédiatrie, Hôpital Femme Mère Enfant
Bron, France, 69677
Service de Cardiologie Pédiatrique, Hôpital Cardiovasculaire L. Pradel
Bron, France, 69677
Service Cardiologie, CHU St Jacques
Clermont-Ferrand, France, 63000
Département de Pédiatrie- Service de Cardiologie, CHU Grenoble
Grenoble, France, 38043
Service de Néphrologie Pédiatrique, CHRU de Lille
Lille, France, 59000
Service des Maladies Cardiovasculaires Infantiles et Congénitales, CHRU Lille
Lille, France, 59000
Service de Cardiologie Infantile, CHU Nancy
Nancy, France, 54511
Service de Cardiologie Pédiatrique, Hôpital Necker Enfants Malades
Paris, France, 75015
Service de Physiologie, Explorations Fonctionnelles, Hôpital Robert Debré
Paris, France, 75019
Unité de Pharmacologie Clinique, Hôpital Robert Debré
Paris, France, 75019
Service de Pathologie Cardiaque Congénitale du Fœtus, de l'Enfant et de l'Adulte, Hôpital Haut Lévêque, CHU de Bordeaux
Pessac, France, 33604
Service de Génétique Médicale, CHU La Milétrie
Poitiers, France, 86021
Service de Cardiologie - Hôpital des Enfants
Toulouse, France, 31059
Service de Néphrologie Pédiatrique - Hôpital des Enfants, CHU Toulouse
Toulouse, France, 31059 收起 <<
United States, California
... 展开 >>
Pfizer Investigational Site
La Jolla, California, United States, 92037
Pfizer Investigational Site
San Francisco, California, United States, 94102
Pfizer Investigational Site
Vallejo, California, United States, 94503
United States, Colorado
Pfizer Investigational Site
Denver, Colorado, United States, 80012
United States, Connecticut
Pfizer Investigational Site
New Haven, Connecticut, United States, 06510
United States, Minnesota
Pfizer Investigational Site
Fridley, Minnesota, United States, 55421
Pfizer Investigational Site
Minneapolis, Minnesota, United States, 55401
United States, North Carolina
Pfizer Investigational Site
Durham, North Carolina, United States, 27701
United States, Ohio
Pfizer Investigational Site
Cincinnati, Ohio, United States, 45202
Pfizer Investigational Site
Cleveland, Ohio, United States, 44101
United States, Oregon
Pfizer Investigational Site
Portland, Oregon, United States, 97201
United States, Pennsylvania
Pfizer Investigational Site
Hershey, Pennsylvania, United States, 17033
United States, Texas
Pfizer Investigational Site
Austin, Texas, United States, 78701
Pfizer Investigational Site
Dallas, Texas, United States, 75201
United States, Utah
Pfizer Investigational Site
Salt Lake City, Utah, United States, 84101 收起 <<
United States, Arkansas
... 展开 >>
Burke Pharmaceutical Research
Hot Springs, Arkansas, United States, 71913
United States, Minnesota
University of Minnesota
Minneapolis, Minnesota, United States, 55455
United States, New Mexico
Academic Dermatology Associates
Albuquerque, New Mexico, United States, 87106
United States, North Carolina
Duke University Medical Center
Durham, North Carolina, United States, 27710
United States, Oregon
Oregon Medical Research Center, P.C.
Portland,, Oregon, United States, 97223
NW Dermatology and Research Center
Portland, Oregon, United States, 97210
United States, Texas
DermResearch, Inc
Austin, Texas, United States, 78759
United States, Utah
Dermatology Research Center, Inc.
Salt Lake City, Utah, United States, 84124
Canada, British Columbia
The Skin Care Centre
Vancouver, British Columbia, Canada, V5Z 4E8
France
Centre de Santé Sabouraud
Paris, Île-de-France, France, 75010
Germany
Klinik für Dermatologie, Venerologie und Allergologie, Clinical Research Center for Hair and Skin Science
Berlin, Germany, 10117
United Kingdom
Royal Hallamshire Hospital
Sheffield, South Yorkshire, United Kingdom, S10 2JF 收起 <<
Germany
... 展开 >> Charité-Universitätsmedizin Berlin, Clinical Research Center for Hair and Skin Science, Dept. of Dermatology, Venereology and Allergy
Berlin, Germany, 10117 收起 <<
Female Pattern Hair Loss
... 展开 >> Androgenetic Alopecia (AGA)
Ludwig Type 1
Ludwig Type 2 收起 <<
Phase 2
Completed
-
Russian Federation
... 展开 >>
State Scientific Center of Dermatology and Cosmetology
Moscow, Russian Federation, 107076
Moscow Scientific Clinical Center of Dermatology and Cosmetology
Moscow, Russian Federation, 119071 收起 <<
United States, Arizona
... 展开 >>
Physicians Hair Institute
Tucson, Arizona, United States, 85719
United States, Tennessee
Tennessee Clinical Research Center
Nashville, Tennessee, United States, 37215
Australia
Sinclair Dermatology
East Melbourne, Australia, 3002
India
LTM Medical College & Hospital
Mumbai, India, 400022
Italy
Istituto Medico Tricologico/Studi Life Cronos
Florence, Italy, 50127 收起 <<
United States, Arizona
... 展开 >>
Physicians Hair Institute
Tucson, Arizona, United States, 85719
United States, Tennessee
Tennessee Clinical Research Center
Nashville, Tennessee, United States, 37215
Australia
Sinclair Dermatology
East Melbourne, Australia, 3002
India
LTM Medical College & Hospital
Mumbai, India, 400022
Italy
Istituto Medico Tricologico/Studi Life Cronos
Florence, Italy, 50127 收起 <<
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