产品说明书
Minoxidil
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同义名 : | 米诺地尔 ;U10858;Loniten;Minoxidil, Loniten, Rogaine, U 10858 |
| CAS号 : | 38304-91-5 | |
| 货号 : | A141385 | |
| 分子式 : | C9H15N5O | |
| 纯度 : | 95% | |
| 分子量 : | 209.25 | |
| MDL号 : | MFCD00063409 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Room temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 10 mg/mL(47.79 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 1 mg/mL(4.78 mM)，配合低频超声，并水浴加热至45℃助溶 无水乙醇: 7 mg/mL(33.45 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Minoxidil (U10858) is an ATP-sensitive potassium (KATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil is also a potent inhibitor of soybean lipoxygenaseare with an IC50 of 20 μM. Minoxidil (0.01 mmoL/kg body weight; intraperitoneal injection; for 3.5 hours; fisher 344 rats) treatment inhibits carrageenan-induced rat paw oedema with an inhibitory potency (49%)[3]. Minoxidil induces generalized hypertrichosis when administered systemically, or localized hair regrowth when applied topically to sites of severe alopecia areata. In the presence of minoxidil, cultures showed a marked dose-dependent second peak of DNA synthesis 8-10 days after culture initiation in epidermal cells. In addition, two morphologically distinct cell types appeared[4]. Minoxidil is a potassium channel opener, causing hyperpolarization of cell membranes and it is also a vasodilator, by widening blood vessels and opening potassium channels, it allows more oxygen, blood and nutrients to the follicle. This can also cause follicles in the telogen phase to shed, usually soon to be replaced by new, thicker hairs in a new anagen phase. The most common adverse reactions of the topical formulation are limited to irritant and allergic contact dermatitis on the scalp[5]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT00283686 | Kidney, Polycystic | Phase 3 | Completed | - | United States, Colorado ... 展开 >> University of Colorado Health Sciences Center Denver (Aurora), Colorado, United States, 800045 United States, Georgia Emory University School of Medicine Atlanta, Georgia, United States, 30322 United States, Kansas University of Kansas Medical Center Kansas City, Kansas, United States, 66160 United States, Massachusetts Tufts University-New England Medical Center Boston, Massachusetts, United States, 02111 Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 United States, Ohio Cleveland Clinic Foundation Cleveland, Ohio, United States, 44195 收起 << |
| NCT00283686 | - | Completed | - | - | |
| NCT01227031 | - | Unknown | July 2011 | Taiwan ... 展开 >> Taipei Medical University-Wan Fang Hospital Not yet recruiting Taipei, Taiwan Contact: Ren-Yu Tsai 886-2-29307930 ext 2980 b671022@tmu.edu.tw 收起 << | |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
4.78mL 0.96mL 0.48mL |
23.89mL 4.78mL 2.39mL |
47.79mL 9.56mL 4.78mL |
| 参考文献 |
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