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橙皮内酯水合物 /Meranzin hydrate {[allProObj[0].p_purity_real_show]}

货号:A141657

Meranzin, a natural product isolated and purified from the roots of Angelica biserrata, produces a rapid effect mediated by AMPA receptors and involving BDNF modulation through the ERK1/2 pathway. Meranzin can also induce similar effect to Fructus Aurantii on intestinal motility and it was, at least in part, mediated by stimulation of H1 histamine receptors, and exhibits antidepressive and prokinetic-like effects through the regulation of the common mediator, the alpha 2-adrenoceptor , and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors.

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Meranzin hydrate 化学结构 CAS号:5875-49-0
Meranzin hydrate 化学结构
CAS号:5875-49-0
Meranzin hydrate 3D分子结构
CAS号:5875-49-0
Meranzin hydrate 化学结构 CAS号:5875-49-0
Meranzin hydrate 3D分子结构 CAS号:5875-49-0
规格 价格 会员价 库存 数量
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Meranzin hydrate 纯度/质量文件 产品仅供科研

货号:A141657 标准纯度: {[allProObj[0].p_purity_real_show]}
批次查询: 批次纯度:

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产品名称 ERK ERK1 ERK2 ERK5 其他靶点 纯度
DEL-22379 +

ERK, IC50: 0.5 μM

+

ERK, IC50: 0.5 μM

98%
Pluripotin ++

ERK1, Kd: 98 nM

RasGAP 98+%
FR 180204 +

ERK1, Ki: 0.31 μM

++

ERK2, Ki: 0.14 μM

98%
Ravoxertinib +++

ERK1, IC50: 1.1 nM

++++

ERK2, IC50: 0.3 nM

99%+
SCH772984 +++

ERK1, IC50: 4 nM

++++

ERK2, IC50: 1 nM

99%+
Temuterkib +++

ERK1, IC50: 5 nM

+++

ERK2, IC50: 5 nM

99%+
VX-11e +++

ERK2, Ki: <2 nM

99%+
Ulixertinib ++++

ERK2, IC50: <0.3 nM

99%+
XMD17-109 ++

ERK5, IC50: 162 nM

99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Meranzin hydrate 生物活性

描述 Meranzin, a natural product isolated and purified from the roots of Angelica biserrata, produces a rapid effect mediated by AMPA receptors and involving BDNF modulation through the ERK1/2 pathway. Meranzin can also induce similar effect to Fructus Aurantii on intestinal motility and it was, at least in part, mediated by stimulation of H1 histamine receptors, and exhibits antidepressive and prokinetic-like effects through the regulation of the common mediator, the alpha 2-adrenoceptor , and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors.

Meranzin hydrate 参考文献

[1]Xie W, Qiu X, et al. Comparison between the pharmacokinetics of meranzin hydrate in a rat model of chronic depression and in controls following the oral administration of Chaihu-Shugan-San. Exp Ther Med. 2013 Oct;6(4):913-918.

[2]Qiu XJ, Huang X, et al. Pharmacokinetic study of the prokinetic compounds meranzin hydrate and ferulic acid following oral administration of Chaihu-Shugan-San to patients with functional dyspepsia. J Ethnopharmacol. 2011 Sep 1;137(1):205-13.

Meranzin hydrate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.59mL

0.72mL

0.36mL

17.97mL

3.59mL

1.80mL

35.93mL

7.19mL

3.59mL

Meranzin hydrate 技术信息

CAS号5875-49-0
分子式C15H18O5
分子量 278.3
别名
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Store in freezer, under -20°C

溶解度

DMSO: 105 mg/mL(377.29 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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