MS4077 is a PROTAC targeting on ALK with DC50 value of 3nM, consist of ALK inhibitor ceritinib as a warhead linked to CRBN ligand Pomalidomide.
规格 | 价格 | 会员价 | 库存 | 数量 | |||
---|---|---|---|---|---|---|---|
{[ item.pr_size ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_am, item.pr_size) ]} | {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} | 现货 | 咨询 | - + |
快速发货 顺丰冷链运输,1-2 天到达
品质保证
技术支持
免费溶解
产品名称 | ALK ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ASP3026 |
+
ALK, IC50: 3.5 nM |
99%+ | |||||||||||||||||
ALK-IN-1 |
++++
ALK, IC50: 0.07 nM |
98+% | |||||||||||||||||
Crizotinib |
++++
ROS1, Ki: <0.025 nM ALK, IC50: 24 nM |
98% | |||||||||||||||||
Entrectinib | ✔ | 99%+ | |||||||||||||||||
Brigatinib |
+++
ROS1, IC50: 1.9 nM ALK, IC50: 0.37 nM |
FLT3 | 98% | ||||||||||||||||
NVP-TAE 684 |
+
ALK, IC50: 3 nM |
99%+ | |||||||||||||||||
Alectinib |
++
ALK (F1174L), IC50: 3.5 nM ALK, IC50: 1.9 nM |
98% | |||||||||||||||||
Ceritinib |
+++
ALK, IC50: 0.2 nM |
Insulin Receptor,IGF-1R | 98% | ||||||||||||||||
GSK1838705A |
+++
ALK, IC50: 0.5 nM |
Insulin Receptor,IGF-1R | 99% | ||||||||||||||||
AZD-3463 |
++
ALK, Ki: 0.75 nM |
IGF-1R | 99% | ||||||||||||||||
Lorlatinib |
++++
ROS1, Ki: <0.07 nM ALK (L1196M), Ki: 0.07 nM |
98% | |||||||||||||||||
Repotrectinib |
+
ALK(G1202R), IC50: 1.26 nM ALK(L1196M), IC50: 1.01 nM |
Src | 99% | ||||||||||||||||
Belizatinib |
++
ALK, IC50: 0.7 nM |
99%+ | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | MS4077 is a PROTAC targeting on ALK with DC50 value of 3nM, consist of ALK inhibitor ceritinib as a warhead linked to CRBN ligand Pomalidomide. Treatment with MS4077 led a degradation of both ALK fusion protein, including NPM-ALK of SU-DHL-1 cells and EML4-ALK of NCI-H2228 cells, as well as downregulation of ALK auto phosphorylation and down-steam STAT3 phosphorylation, in both cell lines in a dose-dependent manner at concentration ranging in 1-100nM for 16h and in a time-dependent manner at concentration of 30nM for SU-DHL-1 cells or 60nM for NCI-H2228 cells within 24h. MS4077 exhibited potent antiproliferation against SU-DHL-1 cells with IC50 value of 46nM post 3 days. MS4748 and MS4740 work as the negative controls for MS4077[1]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
0.88mL 0.18mL 0.09mL |
4.41mL 0.88mL 0.44mL |
8.81mL 1.76mL 0.88mL |
CAS号 | 2230077-10-6 |
分子式 | C55H72ClN9O13S |
分子量 | 1134.73 |
别名 | |
运输 | 蓝冰 |
存储条件 |
液体 -20°C:3-6个月-80°C:12个月 粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
溶解度 |
DMSO: 105 mg/mL(92.53 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |