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MPEP HCl {[allProObj[0].p_purity_real_show]}

货号:A303368 同义名: MPEP (hydrochloride);MPEP Hydrochloride Ambeed 开学季,买赠积分,赢豪礼

MPEP HCl is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype with IC50 of 36 nM.

MPEP HCl 化学结构 CAS号:219911-35-0
MPEP HCl 化学结构
CAS号:219911-35-0
MPEP HCl 3D分子结构
CAS号:219911-35-0
MPEP HCl 化学结构 CAS号:219911-35-0
MPEP HCl 3D分子结构 CAS号:219911-35-0
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MPEP HCl 纯度/质量文件 产品仅供科研

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MPEP HCl 生物活性

描述 MPEP Hydrochloride is a potent, selective, noncompetitive, orally active mGlu5 receptor antagonist with an IC50 of 36 nM for inhibiting quisqualate-stimulated phosphoinositide hydrolysis. It exhibits anxiolytic and antidepressant-like effects[1][2]. MPEP Hydrochloride serves as a click chemistry reagent, containing an Alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with Azide-containing molecules.
体内研究

MPEP (1-30 mg/kg) elicits anxiolytic-like effects in various behavioral tests, including the conflict drinking test and the elevated plus-maze test in rats, as well as the four-plate test in mice[2].

MPEP (1-20 mg/kg) reduces the immobility time in a tail suspension test in mice, though it shows no activity in the behavioral despair test in rats[2].

MPEP (30 mg/kg i.p.) significantly increases the number of punished crossings by 39% in the four-plate test, whereas lower doses (3 and 10 mg/kg) do not affect punished crossings in that test (F (3,36)=3.240, P<0.05)[2].

MPEP administered at 1, 10, and 20 mg/kg significantly reduces the immobility time in the tail suspension test in mice by up to 55% after the highest dose (F(3,28)=15.47, P<0.001), demonstrating efficacy comparable to that of imipramine (20 mg/kg), which is used as the positive control[2].

体外研究

MPEP does not exhibit agonistic or antagonistic effects at 100 mM on human mGlu2, -3, -4a, -7b, and -8a receptors, nor at 10 μM on the human mGlu6 receptor[1].

MPEP HCl 参考文献

[1]F Gasparini, et al. 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a Potent, Selective and Systemically Active mGlu5 Receptor Antagonist. Neuropharmacology. 1999 Oct;38(10):1493-503.

[2]E Tatarczyńska, et al. Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist. Br J Pharmacol. 2001 Apr;132(7):1423-30.

MPEP HCl 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.35mL

0.87mL

0.44mL

21.77mL

4.35mL

2.18mL

43.53mL

8.71mL

4.35mL

MPEP HCl 技术信息

CAS号219911-35-0
分子式C14H12ClN
分子量 229.705
别名 MPEP (hydrochloride);MPEP Hydrochloride
运输蓝冰
存储条件

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度

H2O: 25 mg/mL(108.84 mM),配合低频超声,并水浴加热至45℃助溶

动物实验配方
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