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MPEP HCl

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Chemical Structure| 219911-35-0 同义名 : MPEP (hydrochloride);MPEP Hydrochloride
CAS号 : 219911-35-0
货号 : A303368
分子式 : C14H12ClN
纯度 : 99%+
分子量 : 229.705
MDL号 : MFCD02262119
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 25 mg/mL(108.84 mM)，配合低频超声，并水浴加热至45℃助溶
动物实验配方：
生物活性
描述 MPEP Hydrochloride is a potent, selective, noncompetitive, orally active mGlu5 receptor antagonist with an IC50 of 36 nM for inhibiting quisqualate-stimulated phosphoinositide hydrolysis. It exhibits anxiolytic and antidepressant-like effects[1][2]. MPEP Hydrochloride serves as a click chemistry reagent, containing an Alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with Azide-containing molecules.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.35mL

0.87mL

0.44mL

21.77mL

4.35mL

2.18mL

43.53mL

8.71mL

4.35mL
参考文献

[1]F Gasparini, et al. 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a Potent, Selective and Systemically Active mGlu5 Receptor Antagonist. Neuropharmacology. 1999 Oct;38(10):1493-503.

[2]E Tatarczyńska, et al. Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist. Br J Pharmacol. 2001 Apr;132(7):1423-30.