Levomefolate calcium
产品说明书
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同义名 : | L-5-甲基四氢叶酸钙 |
| CAS号 : | 151533-22-1 | |
| 货号 : | A126968 | |
| 分子式 : | C20H23CaN7O6 | |
| 纯度 : | 98% | |
| 分子量 : | 497.518 | |
| MDL号 : | MFCD15146358 | |
| 存储条件： |
Pure form Inert atmosphere,Room Temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
H2O: 4 mg/mL(8.04 mM) |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Levomefolate calcium is an artificial form of folate. It is a coenzymated form of folic acid and a more bioavailable alternative in dietary supplements. A fixed-dose combination of an oral contraceptive and levomefolate calcium leads to sustainable improvements in folate status compared with an oral contraceptive + folic acid[3]. Clinically significant increases in folate status were observed with EE/drsp/levomefolate calcium compared with EE(ethinylestradiol)/drsp alone in US women of childbearing age[4]. The rate and extent of absorption of ethinylestradiol and drospirenone were not affected by the concomitant administration of levomefolate calcium and vice versa[5]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT00468481 | Neural Tube Defects ... 展开 >> Contraception Oral Contraceptives (OC) 收起 << | Phase 3 | Completed | - | United States, California ... 展开 >> Orange County Clinical Trials Anaheim, California, United States, 92801 Medical Center for Clinical Research San Diego, California, United States, 92108 United States, Maryland SNBL Clinical Pharmacology Center, Inc. Baltimore, Maryland, United States, 21201 United States, New York Columbia University Medical Center New York, New York, United States, 10032 United States, North Carolina AAIPharma, Inc. Morrisville, North Carolina, United States, 27560 Lyndhurst Gynecologic Associates Winston-Salem, North Carolina, United States, 27103 United States, South Carolina Coastal Carolina Research Center Mt. Pleasant, South Carolina, United States, 29464 United States, Tennessee New Orleans Center for Clinical Research Knoxville, Tennessee, United States, 37920 United States, Washington NorthWest Kinetics Tacoma, Washington, United States, 98418 收起 << |
| NCT00468481 | - | Completed | - | - | |
| NCT01584050 | Vitamin B12 Deficiency | Not Applicable | Completed | - | Canada, British Columbia ... 展开 >> University of British Columbia Vancouver, British Columbia, Canada Malaysia Universiti Putra Malaysia Serdang, Selangor, Malaysia 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.01mL 0.40mL 0.20mL |
10.05mL 2.01mL 1.00mL |
20.10mL 4.02mL 2.01mL |
| 参考文献 |
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