产品说明书

Levoleucovorin Calcium

Print
Chemical Structure| 80433-71-2 同义名 : Calcium levofolinate;CL307782;5-Formyltetrahydrofolate;L-Folinate;L-Folinic Acid (calcium salt)
CAS号 : 80433-71-2
货号 : A161998
分子式 : C20H23CaN7O7
纯度 : 98%
分子量 : 513.517
MDL号 : MFCD08704249
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 10 mg/mL(19.47 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Calcium Levofolinate is the calcium salt of Levoleucovorin, which is the enantiomerically active form of folinic acid. Levoleucovorin is used to treat or prevent toxic effects of methotrexate in people who have received methotrexate to treat bone cancer. Levoleucovorin is also used in combination chemotherapy with fluorouracil (5-FU) to treat colorectal cancer that has spread to other parts of the body. This medicine only treats the symptoms of colorectal cancer and does not treat the cancer itself. In the combination of Leucovorin (LV) and 5-fluorouracil (5-FU), LV potentiates the cytotoxic effect of 5-FU based on biochemical modulation[3]. A 4-week toxicity study of 5-FU (10 mg/kg/day) in combination with 1-LV (6, 20 or 60 mg/kg/day) was conducted in rats. In the group for which 5-FU was combined with 1-LV, the RBC counts decreased, extramedullary hematopoiesis increased and the suppression of lymphatic organs was enhanced. Changes in the lymphatic organs were observed at 20 mg/kg/day of 1-LV and above. The potentiation induced by 1-LV in the toxicity of 5-FU appeared to be mainly immuno-suppression and myelosuppression, which were related to the anti-tumor activity of 5-FU[4].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02047474 Acinar Cell Adenocarcinoma of ... 展开 >>the Pancreas Duct Cell Adenocarcinoma of the Pancreas Stage I Pancreatic Cancer Stage IIA Pancreatic Cancer Stage IIB Pancreatic Cancer 收起 << Phase 2 Recruiting December 2020 United States, Connecticut ... 展开 >> Yale University Recruiting New Haven, Connecticut, United States, 06520-8032 Contact: Kamil Sadowski    203-785-6661    kamil.sadowski@yale.edu    Principal Investigator: Jill Lacy 收起 <<
NCT01320683 Liver Metastases ... 展开 >> Recurrent Colon Cancer Recurrent Rectal Cancer Stage IVA Colon Cancer Stage IVA Rectal Cancer Stage IVB Colon Cancer Stage IVB Rectal Cancer 收起 << Phase 2 Terminated(Slow accrual.) - United States, California ... 展开 >> City of Hope Medical Center Duarte, California, United States, 91010 收起 <<
NCT01959139 Metastatic Pancreatic Adenocar... 展开 >>cinoma 收起 << Phase 1 Phase 2 Active, not recruiting October 2020 -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.95mL

0.39mL

0.19mL

9.74mL

1.95mL

0.97mL

19.47mL

3.89mL

1.95mL
参考文献

[1]Willems FF, Boers GH, et al. Pharmacokinetic study on the utilisation of 5-methyltetrahydrofolate and folic acid in patients with coronary artery disease. Br J Pharmacol. 2004 Mar;141(5):825-30.

[2]Murakami Y, Fujii H, et al. Effects of levofolinate calcium on subacute intravenous toxicity of 5-fluorouracil in rats. J Toxicol Sci. 1998 May;23 Suppl 1:11-29.

[3]Sasaki T. [Combination of levofolinate calcium and 5-fluorouracil]. Gan To Kagaku Ryoho. 2000 Feb;27(2):315-22. Japanese

[4]Murakami Y, Fujii H, Ichimura A, Murata A, Yamashita N, Takagi H, Tauchi K. Effects of levofolinate calcium on subacute intravenous toxicity of 5-fluorouracil in rats. J Toxicol Sci. 1998 May;23 Suppl 1:11-29