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描述 | LDN-192960 is an inhibitor of both Haspin and Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2), exhibiting IC50 values of 10 nM and 48 nM, respectively [1]. |
体外研究 | At a concentration of 10 μM, LDN-192960 exhibits selectivity and inhibits over 90% of ten other kinases, with only five showing potent inhibition (IC50<1 μM), including CLK1 (IC50=0.21 μM). LDN-0192960 (0-5 μM; 2 hours) exhibits the characteristic inhibition profile of Haspin by decreasing p-Thr3H3 levels in HeLa cells overexpressing Haspin, with an EC50 of 1.17 μM [2]. LDN-0192960 (0-1 μM; 1 hour incubation in the presence of nocodazole and MG132) demonstrates the typical Haspin inhibition pattern by reducing p-Thr3H3 levels in mitotically synchronized HeLa cells, with an EC50 of 0.02 μM [2]. |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
3.04mL 0.61mL 0.30mL |
15.22mL 3.04mL 1.52mL |
30.45mL 6.09mL 3.04mL |
CAS号 | 184582-62-5 |
分子式 | C18H20N2O2S |
分子量 | 328.429 |
别名 | |
运输 | 蓝冰 |
存储条件 |
粉末 Keep in dark place,Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 25 mg/mL(76.12 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |