Isotretinoin, an analogue of retinoic acid, is an agonist of retinoic acid receptors that is used for the treatment of severe acne.
HazMat Fee +
There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Isotretinoin (13-cis-Retinoic acid) is an orally active derivative of vitamin A commonly used in the treatment of severe acne. It also exhibits anticancer activity[1][2].
体内研究
Isotretinoin (13-cis-Retinoic acid), administered through inhalation exposure at concentrations ranging from 1.3 to 481 μg/L for 45 minutes daily over 2 weeks, proves to be an effective chemopreventive agent against lung cancer in A/J Mice[2].
Isotretinoin expedites alveolar repair following exodontia in rats[3].
体外研究
Isotretinoin (13-cis-Retinoic acid) may function as a pro-drug that undergoes intracellular conversion to metabolites acting as agonists for RAR and RXR nuclear receptors[1].
Isotretinoin is highly susceptible to degradation by air, heat, and light[3].
Isotretinoin significantly inhibits HepG2 cell viability over a duration of 24-96 hours and at concentrations ranging from 0 to 40 μM[4].
Isotretinoin, at a concentration of 10 μM for 48 hours, down-regulates c-MYC mRNA expression, which is partially attributed to the activity of the P1 or P2 promoter[4].
搜索
HazMat Fee +
