The aryl hydrocarbon receptor (AHR) is a ligand-inducible transcription factor that is best known because it mediates the actions of polycyclic and halogenated aromatic hydrocarbon environmental toxicants such as 3-methylcholanthrene and 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin. ITE is a ligand that binds directly to the AHR to induce receptor activity with Ki of 3 nM [3]. Treatment with ITE inhibited the cellular immune responses against the uveitogenic antigen, interphotoreceptor retinoid-binding protein (IRBP), and the CFA component, PPD, as measured in vitro. Treatment with ITE by daily intraperitoneal injection of 0.2 mg efficiently inhibited the development of EAU in B10.A mice induced by immunization with IRBP of 40 μg. Further learning about the effect of ITE treatment on the immune system showed that the proportions of cells expressing IFN-γ or IL-17 were lower in the ITE-treated mice than in their controls [4].
United States, Tennessee
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Mountain Home VA Medical Center James H. Quillen VA Medical Center, Mountain Home, TN
Not yet recruiting
Mountain Home, Tennessee, United States, 37684
Contact: Sherri L Smith, PhD 423-926-1171 ext 7569 sherri.smith@va.gov
Principal Investigator: Sherri L. Smith, PhD 收起 <<
ALK-negative Anaplastic Large ... 展开 >>Cell Lymphoma
Peripherial T Cell Lymphoma,Not Otherwise Specified
Angioimmunoblastic T Cell Lymphoma
Enteropathy Associated T Cell Lymphoma
Hepatosplenic T Cell Lymphoma
Subcutaneous Panniculitis Like T Cell Lymphoma 收起 <<
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