产品说明书

ITE

Print
Chemical Structure| 448906-42-1 同义名 : -
CAS号 : 448906-42-1
货号 : A163287
分子式 : C14H10N2O3S
纯度 : 98%
分子量 : 286.306
MDL号 : MFCD06411597
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 40 mg/mL(139.71 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 The aryl hydrocarbon receptor (AHR) is a ligand-inducible transcription factor that is best known because it mediates the actions of polycyclic and halogenated aromatic hydrocarbon environmental toxicants such as 3-methylcholanthrene and 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin. ITE is a ligand that binds directly to the AHR to induce receptor activity with Ki of 3 nM [3]. Treatment with ITE inhibited the cellular immune responses against the uveitogenic antigen, interphotoreceptor retinoid-binding protein (IRBP), and the CFA component, PPD, as measured in vitro. Treatment with ITE by daily intraperitoneal injection of 0.2 mg efficiently inhibited the development of EAU in B10.A mice induced by immunization with IRBP of 40 μg. Further learning about the effect of ITE treatment on the immune system showed that the proportions of cells expressing IFN-γ or IL-17 were lower in the ITE-treated mice than in their controls [4].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00386100 Diabetes Mellitus, Type 2 Phase 4 Completed - -
NCT01243424 Diabetes Mellitus, Type 2 Phase 3 Completed - -
NCT03108768 Hearing Loss, Bilateral Sensor... 展开 >>ineural, Progressive 收起 << Not Applicable Completed - Switzerland ... 展开 >> Sonova AG Stafa, Zürich, Switzerland, 8712 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.49mL

0.70mL

0.35mL

17.46mL

3.49mL

1.75mL

34.93mL

6.99mL

3.49mL
参考文献

[1]Wang K, Li Y, et al. An endogenous aryl hydrocarbon receptor ligand inhibits proliferation and migration of human ovarian cancer cells. Cancer Lett. 2013 Oct 28;340(1):63-71.

[2]Song J, Clagett-Dame M, et al. A ligand for the aryl hydrocarbon receptor isolated from lung. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14694-9.

[3]Song J, Clagett-Dame M, Peterson RE, Hahn ME, Westler WM, Sicinski RR, DeLuca HF. A ligand for the aryl hydrocarbon receptor isolated from lung. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14694-9. doi: 10.1073/pnas.232562899. Epub 2002 Oct 30. PMID: 12409613; PMCID: PMC137481.

[4]Nugent LF, Shi G, Vistica BP, Ogbeifun O, Hinshaw SJ, Gery I. ITE, a novel endogenous nontoxic aryl hydrocarbon receptor ligand, efficiently suppresses EAU and T-cell-mediated immunity. Invest Ophthalmol Vis Sci. 2013 Nov 13;54(12):7463-9. doi: 10.1167/iovs.12-11479. PMID: 24150760; PMCID: PMC3828045.