Hydroxycitric acid, a natural product isolated and purified from the fruits of Garcinia atroviridis, can inhibit fat synthesis and reduces food intake, the primary mechanism of action of HCA appears to be related to its ability to act as a competitive inhibitor of the enzyme ATP-citrate lyase, which catalyzes the conversion of citrate and coenzyme A to oxaloacetate and acetyl coenzyme A (acetyl-CoA), primary building blocks of fatty acid and cholesterol synthesis, and ameliorate high-fructose-induced redox imbalance and activation of stress sensitive kinases in male Wistar rats through its hypolipidemic effects.
Hydroxycitric acid, the active ingredient in the herbal compound Garcinia cambogia, competitively inhibits the extramitochondrial enzyme adenosine triphosphate-citrate (pro-3S)-lyase[3]. Hydroxycitric Acid ((-)-Hydroxycitric acid (HCA)) is an active ingredient extracted from the rind of the Indian fruit Garcinia cambogia. It inhibits adenosine triphosphate citrate lyase and has been used in the treatment of obesity[4]. (-)-hydroxycitric acid (HCA) inhibits the enzyme ATP-dependent citrate lyase, which catalyzes the cleavage of citrate to oxaloacetate and acetyl-CoA[5]. HCA treatment could reduce markers of renal impairment (Blood Urea Nitrogen and serum creatinine). There was significantly less calcium oxalate crystal deposition in mice treated with HCA. Calcium oxalate crystals induced the production of reactive oxygen species and reduced the activity of antioxidant defense enzymes. HCA attenuated oxidative stress induced by calcium oxalate crystallization. HCA had inhibitory effects on calcium oxalate-induced inflammatory cytokines, such as MCP-1, IL-1β, and IL-6. In addition, HCA alleviated tubular injury and apoptosis caused by calcium oxalate crystals[6].
United States, New York
... 展开 >>
New York University School of Medicine
Not yet recruiting
New York, New York, United States, 10016
Contact: David Goldfarb, MD 212-263-0744 david.goldfarb@nyumc.org
Principal Investigator: David Goldfarb, MD 收起 <<
搜索
