SB 204990是一种有效的ATP柠檬酸裂解酶 (ACLY) 特异性抑制剂，能够调节脂质合成代谢，适用于相关代谢紊乱研究。

BMS-303141是一种强效的 ATP-citrate lyase (ACL) 抑制剂，IC50 为 0.13 μM（人类重组 ACL），可抑制 HepG2 细胞中的总脂质合成（IC50 = 8 μM）。

NDI-091143是一种人类 ACLY 的小分子抑制剂，作用于柠檬酸结合位点旁边的变构疏水腔，需要酶的广泛构象变化来间接破坏柠檬酸结合。

MEDICA 16 is a free fatty acid 1 (FFA1/GPR40) receptor agonist.

Hydroxycitric acid tripotassium hydrate是来自Garcinia cambogia的主要活性成分，是柠檬酸的衍生物。它通过竞争性抑制ATP柠檬酸裂解酶，具有减肥效果。此外，它能有效抑制结石的形成，抑制HIF，并具有抗氧化、抗炎和抗肿瘤作用。

Hydroxycitric acid, a natural product isolated and purified from the fruits of Garcinia atroviridis, can inhibit fat synthesis and reduces food intake, the primary mechanism of action of HCA appears to be related to its ability to act as a competitive inhibitor of the enzyme ATP-citrate lyase, which catalyzes the conversion of citrate and coenzyme A to oxaloacetate and acetyl coenzyme A (acetyl-CoA), primary building blocks of fatty acid and cholesterol synthesis, and ameliorate high-fructose-induced redox imbalance and activation of stress sensitive kinases in male Wistar rats through its hypolipidemic effects.