产品说明书
Hydroxycitric Acid
 |
同义名 : | HCA;(±)-Hydroxycitric Acid |
| CAS号 : | 6205-14-7 | |
| 货号 : | A511499 | |
| 分子式 : | C6H8O8 | |
| 纯度 : | 95% | |
| 分子量 : | 208.123 | |
| MDL号 : | MFCD02093093 | |
| 存储条件： |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Hydroxycitric acid, the active ingredient in the herbal compound Garcinia cambogia, competitively inhibits the extramitochondrial enzyme adenosine triphosphate-citrate (pro-3S)-lyase[3]. Hydroxycitric Acid ((-)-Hydroxycitric acid (HCA)) is an active ingredient extracted from the rind of the Indian fruit Garcinia cambogia. It inhibits adenosine triphosphate citrate lyase and has been used in the treatment of obesity[4]. (-)-hydroxycitric acid (HCA) inhibits the enzyme ATP-dependent citrate lyase, which catalyzes the cleavage of citrate to oxaloacetate and acetyl-CoA[5]. HCA treatment could reduce markers of renal impairment (Blood Urea Nitrogen and serum creatinine). There was significantly less calcium oxalate crystal deposition in mice treated with HCA. Calcium oxalate crystals induced the production of reactive oxygen species and reduced the activity of antioxidant defense enzymes. HCA attenuated oxidative stress induced by calcium oxalate crystallization. HCA had inhibitory effects on calcium oxalate-induced inflammatory cytokines, such as MCP-1, IL-1β, and IL-6. In addition, HCA alleviated tubular injury and apoptosis caused by calcium oxalate crystals[6]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT00699413 | Obesity Diabe... 展开 >>tes Mellitus, Type 2 收起 << | Phase 4 | Terminated(Sponsor decided to ... 展开 >>withdraw from study.) 收起 << | - | United States, California ... 展开 >> USC - Preventive Medicine Los Angeles, California, United States, 90033 收起 << |
| NCT00699413 | - | Terminated(Sponsor decided to ... 展开 >>withdraw from study.) 收起 << | - | - | |
| NCT01238887 | Obesity Oxida... 展开 >>tive Stress 收起 << | Phase 1 Phase 2 | Terminated(Some capsules used ... 展开 >>in this study were been found to be cracked and leaking.) 收起 << | - | United States, Florida ... 展开 >> University of Florida General Clinical Research Center (GCRC) Gainesville, Florida, United States, 32608 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
4.80mL 0.96mL 0.48mL |
24.02mL 4.80mL 2.40mL |
48.05mL 9.61mL 4.80mL |
| 参考文献 |
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