货号:A256420 同义名: 1-肼苯哒嗪盐酸盐 / Hydralazine (hydrochloride);1-Hydrazinophthalazine
Hydralazine HCl is a direct-acting vasodilator that is used as an antihypertensive agent.
There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
规格 | 价格 | 会员价 | 库存 | 数量 | |||
---|---|---|---|---|---|---|---|
{[ item.pr_size ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} | {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} | 现货 | 咨询 | - + |
快速发货 顺丰冷链运输,1-2 天到达
品质保证
技术支持
免费溶解
产品名称 | Potassium Channel ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tolbutamide | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Glimepiride |
++++
SUR2B, IC50: 7.3 nM SUR1, IC50: 5.4 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Dronedarone Hydrochloride | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Gliquidone |
++
Potassium channel, IC50: 27.2 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
TRAM-34 |
+++
IKCa1 (KCa3.1), Kd: 20 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Glibenclamide | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Amiodarone HCl | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Gliclazide |
++
Potassium channel, IC50: 184 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Repaglinide | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Dofetilide | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Nateglinide | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Quinine hydrochloride dihydrate | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
ML133 HCl |
+
Kir2.1, IC50: 290 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | Hydralazine hydrochloride (HHC) is a direct-acting smooth muscle relaxant used to treat hypertension by acting as a vasodilator primarily in arteries and arterioles. The preliminary IV administration of dihydralazine allowed a reduced volatile agent concentration which attenuated undesirable haemodynamic effects, in spite of renin and norepinephrine release, and permitted a rapid intraoperative awakening[3]. Hydralazine hydrochloride may reduce blood pressure when compared to placebo in patients with primary hypertension, however this data is based on before and after studies, not RCTs (randomized controlled trials)[4]. The suitability of the prepared HHC sublingual tablets for use in rapid control on hypertensive crisis especially in pregnant women as an alternate to parenteral administration[5]. The combination consists of 20 mg of isosorbide and 37.5 mg hydralazine hydrochloride in a fixed dose that functions as a nitric oxide enhancer and an antioxidant, and helps to prevent tolerance to the prolonged use of nitrate[6]. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT02884011 | - | Completed | - | United States, Illinois ... 展开 >> Rush Univeristy Medical Center Chicago, Illinois, United States, 60612 收起 << | |
NCT03608085 | Heart Failure | Not Applicable | Recruiting | May 31, 2019 | United States, Rhode Island ... 展开 >> Ocean State Research Institute Recruiting Providence, Rhode Island, United States, 02908 Contact: Mary Ford 401-273-7100 ext 3674 Mary.Ford@va.gov Principal Investigator: Tracey H Taveira, Pharm.D. Sub-Investigator: Philip Haines, MD Sub-Investigator: Wen-Chih Wu, MD Providence VAMC Recruiting Providence, Rhode Island, United States, 02908 Contact: Melanie R Parent, Ba 401-273-7100 ext 6293 Melanie.Parent@va.gov Principal Investigator: Tracey H Taveira, Pharm.D. 收起 << |
NCT03619317 | - | Recruiting | August 2020 | Denmark ... 展开 >> University Hospital of Aarhus, Department of Cardiology Recruiting Aarhus N, Denmark, 8200 Contact: Mette Søndergaard 30130565 metast@rm.dk Contact: Steen Poulsen steen.hvitfeldt@rm.dk 收起 << | |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
5.09mL 1.02mL 0.51mL |
25.43mL 5.09mL 2.54mL |
50.86mL 10.17mL 5.09mL |
CAS号 | 304-20-1 |
分子式 | C8H9ClN4 |
分子量 | 196.637 |
别名 | 1-肼苯哒嗪盐酸盐 ;Hydralazine (hydrochloride);1-Hydrazinophthalazine;Nepresol;mono-Hydrochloride, Hydralazine;Hydralazine chloride;Apresoline;Aiselazine;1-Hydrazinophthalazine hydrochloride;Hydralazine hydrochloride |
运输 | 蓝冰 |
存储条件 |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 25 mg/mL(127.14 mM),配合低频超声,并调节pH至11,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO H2O: 25 mg/mL(127.14 mM),配合低频超声助溶 |
动物实验配方 |
PO 0.5% CMC-Na 31 mg/mL suspension |