货号:A405837 同义名: 2-羟丙基-β-环糊精;羟丙基-BETA-环糊精 / (2-Hydroxypropyl)-β-cyclodextrin;2-Hydroxypropyl-β-cyclodextrin
羟丙基-β-环糊精(HP-β-CD)是一种无定形物质,具有极高的水溶性。它在药物递送载体领域得到了广泛的应用,并且是环糊精衍生物中研究最为广泛的一种,对于提高药物的溶解度和稳定性具有显著效果。
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快速发货 顺丰冷链运输,1-2 天到达
品质保证
技术支持
免费溶解
描述 | 2-Hydroxypropyl-β-cyclodextrin (HP-β-CyD) is a cyclic oligosaccharide that is widely used as an enabling excipient in pharmaceutical formulations, but also as a cholesterol modifier. HP-β-CyD treatment reduced intracellular cholesterol resulting in significant leukemic cell growth inhibition through G2/M cell-cycle arrest and apoptosis. Intraperitoneal injection of HP-β-CyD significantly improved survival in leukemia mouse models[2]. HPβCD administration promotes transcription factor EB-mediated clearance of proteolipid aggregates that accumulate due to inefficient activity of the lysosome-autophagy system in cells derived from a patient with a lysosomal storage disorder[3]. HP-β-CD and HP-γ-CD reduce the accumulation of sphingolipids, mainly sphingomyelins, and free cholesterol as well as lysosome changes in Npc1-null, but not in wild-type, CHO cells[4]. HP-β-CD is well tolerated in the animal species tested (rats, mice and dogs), particularly when dosed orally, and shows only limited toxicity[5]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
0.65mL 0.13mL 0.06mL |
3.24mL 0.65mL 0.32mL |
6.49mL 1.30mL 0.65mL |
CAS号 | 128446-35-5 |
分子式 | |
分子量 |
别名 | 2-羟丙基-β-环糊精;羟丙基-BETA-环糊精;(2-羟丙基)-β-环糊精 ;(2-Hydroxypropyl)-β-cyclodextrin;2-Hydroxypropyl-β-cyclodextrin;VTS-270;HP-beta-CyD;HP-beta-CD;HPbCD;THPB;Hydroxypropyl-beta-cyclodextri;Hydroxypropyl-β-cyclodextrin;Hydroxypropyl betadex;HP-β-cyclodextrin |
运输 | 蓝冰 |
存储条件 |
液体 -20°C:3-6个月-80°C:12个月 粉末 Sealed in dry,Room Temperature |
溶解度 | |
动物实验配方 |