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羟丙基-β-环糊精 /HP-β-CD {[allProObj[0].p_purity_real_show]}

货号:A405837 同义名: 2-羟丙基-β-环糊精;羟丙基-BETA-环糊精 / (2-Hydroxypropyl)-β-cyclodextrin;2-Hydroxypropyl-β-cyclodextrin

羟丙基-β-环糊精(HP-β-CD)是一种无定形物质,具有极高的水溶性。它在药物递送载体领域得到了广泛的应用,并且是环糊精衍生物中研究最为广泛的一种,对于提高药物的溶解度和稳定性具有显著效果。

HP-β-CD 化学结构 CAS号:128446-35-5
HP-β-CD 化学结构
CAS号:128446-35-5
HP-β-CD 3D分子结构
CAS号:128446-35-5
HP-β-CD 化学结构 CAS号:128446-35-5
HP-β-CD 3D分子结构 CAS号:128446-35-5
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HP-β-CD 纯度/质量文件 产品仅供科研

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HP-β-CD 生物活性

描述 2-Hydroxypropyl-β-cyclodextrin (HP-β-CyD) is a cyclic oligosaccharide that is widely used as an enabling excipient in pharmaceutical formulations, but also as a cholesterol modifier. HP-β-CyD treatment reduced intracellular cholesterol resulting in significant leukemic cell growth inhibition through G2/M cell-cycle arrest and apoptosis. Intraperitoneal injection of HP-β-CyD significantly improved survival in leukemia mouse models[2]. HPβCD administration promotes transcription factor EB-mediated clearance of proteolipid aggregates that accumulate due to inefficient activity of the lysosome-autophagy system in cells derived from a patient with a lysosomal storage disorder[3]. HP-β-CD and HP-γ-CD reduce the accumulation of sphingolipids, mainly sphingomyelins, and free cholesterol as well as lysosome changes in Npc1-null, but not in wild-type, CHO cells[4]. HP-β-CD is well tolerated in the animal species tested (rats, mice and dogs), particularly when dosed orally, and shows only limited toxicity[5].

HP-β-CD 参考文献

[2]Yokoo M, Kubota Y, Motoyama K, Higashi T, Taniyoshi M, Tokumaru H, Nishiyama R, Tabe Y, Mochinaga S, Sato A, Sueoka-Aragane N, Sueoka E, Arima H, Irie T, Kimura S. 2-Hydroxypropyl-β-Cyclodextrin Acts as a Novel Anticancer Agent. PLoS One. 2015 Nov 4;10(11):e0141946

[3]Song W, Wang F, Lotfi P, Sardiello M, Segatori L. 2-Hydroxypropyl-β-cyclodextrin promotes transcription factor EB-mediated activation of autophagy: implications for therapy. J Biol Chem. 2014 Apr 4;289(14):10211-22

[4]Hoque S, Kondo Y, Sakata N, Yamada Y, Fukaura M, Higashi T, Motoyama K, Arima H, Higaki K, Hayashi A, Komiya T, Ishitsuka Y, Irie T. Differential Effects of 2-Hydroxypropyl-Cyclodextrins on Lipid Accumulation in Npc1-Null Cells. Int J Mol Sci. 2020 Jan 30;21(3):898

[5]Gould S, Scott RC. 2-Hydroxypropyl-beta-cyclodextrin (HP-beta-CD): a toxicology review. Food Chem Toxicol. 2005 Oct;43(10):1451-9

HP-β-CD 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

0.65mL

0.13mL

0.06mL

3.24mL

0.65mL

0.32mL

6.49mL

1.30mL

0.65mL

HP-β-CD 技术信息

CAS号128446-35-5
分子式
分子量
别名 2-羟丙基-β-环糊精;羟丙基-BETA-环糊精;(2-羟丙基)-β-环糊精 ;(2-Hydroxypropyl)-β-cyclodextrin;2-Hydroxypropyl-β-cyclodextrin;VTS-270;HP-beta-CyD;HP-beta-CD;HPbCD;THPB;Hydroxypropyl-beta-cyclodextri;Hydroxypropyl-β-cyclodextrin;Hydroxypropyl betadex;HP-β-cyclodextrin
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Room Temperature

溶解度
动物实验配方
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